Richardson W P, Paterson P Y
Clin Exp Immunol. 1970 Mar;6(3):337-44.
Lymph node cell (LNC) transfers of experimental allergic encephalomyelitis (EAE) in Lewis rats were performed in which suspensions of sensitized LNC, prior to injection into recipients, were incubated with antisera against rat whole serum or rat γ-globulin. No interference with the transfer of EAE was observed. Fluorescent antibody studies revealed essentially no binding of anti-rat globulin to suspensions of intact LNC. Definite binding of anti-rat globulin was demonstrable, however, after alcohol-fixation of LNC. These observations provide additional evidence that immune responses of the delayed-type intimately associated with sensitized lymph node cell suspensions are more important than conventional immunoglobulin responses in development of EAE.
在刘易斯大鼠身上进行了实验性变应性脑脊髓炎（EAE）的淋巴结细胞（LNC）转移实验，即将致敏的LNC悬液在注入受体之前，与抗大鼠全血清或大鼠γ球蛋白的抗血清一起孵育。未观察到对EAE转移的干扰。荧光抗体研究表明，抗大鼠球蛋白与完整LNC悬液基本无结合。然而，在LNC经酒精固定后，可证明抗大鼠球蛋白有明确的结合。这些观察结果提供了额外的证据，表明与致敏淋巴结细胞悬液密切相关的迟发型免疫反应在EAE的发展中比传统的免疫球蛋白反应更重要。
