参与大鼠对巴西日圆线虫肠道阶段保护性免疫的循环免疫球蛋白。
The circulating immunoglobulins involved in protective immunity to the intestinal stage of Nippostrongylus brasiliensis in the rat.
作者信息
Jones V E, Edwards A J, Ogilvie B M
出版信息
Immunology. 1970 May;18(5):621-33.
Antisera taken from rats after one, two or three larval infections with or after one infection of adult worms were separated by chromatography and the fractions were tested for passive protective activity. Irrespective of the number or type of infections given, protection against the parasite was most frequently obtained with fractions of antisera containing predominantly 7Sγ-globulin. γM- and γA-globulins sometimes appeared to contribute to protective activity, but γM-globulin was not the major source of protective antibodies in antisera taken after a primary infection either of adult worms or of larvae. 7Sγ-protective antibodies were found only in a pool of antiserum taken after three infections. Rats were passively protected with antiserum or fractions of antiserum, which were free of reagins and of other identifiable anaphylactic antibodies. It appears that rats can be passively immunized with antisera which do not have anaphylactic activity.
分别取经一、二或三次幼虫感染后的大鼠血清，或经一次成虫感染后的大鼠血清，通过色谱法进行分离，并对各组分进行被动保护活性检测。无论感染的次数或类型如何，主要含有7Sγ球蛋白的抗血清组分最常获得对该寄生虫的保护作用。γM球蛋白和γA球蛋白有时似乎有助于保护活性，但在初次感染成虫或幼虫后采集的抗血清中，γM球蛋白并非保护性抗体的主要来源。仅在三次感染后采集的抗血清混合液中发现了7Sγ保护性抗体。用不含反应素和其他可识别的过敏抗体的抗血清或抗血清组分对大鼠进行被动保护。似乎可以用无过敏活性的抗血清对大鼠进行被动免疫。
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