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与小鼠对带状绦虫抗性的被动转移相关的免疫球蛋白。

Immunoglobulins associated with passive transfer of resistance to Taenia taeniaeformis in the mouse.

作者信息

Musoke A J, Williams J F

出版信息

Immunology. 1975 Jan;28(1):97-101.

PMID:803917
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1445755/
Abstract

Mice were found to be protected against Taenia taeniaforMis infection by passive transfer of serum collected from donors 28 days after infection. The protective activity resided exclusively in the first fraction of 7S immunoglobulins eluting from DEAE-cellulose at pH 5.8 with 0.05 M phosphate buffer. This fraction contained 7Sgamma1 and 7Sgamma2 immunoglobulins but no detectable gammaA, gammaM or skin sensitizing activity. Fractions containing 7Sgamma 2 alone were ineffective in passive transfer.

摘要

研究发现，通过被动转移感染后28天从供体采集的血清，小鼠可免受泡状带绦虫感染。保护活性仅存在于用0.05M磷酸盐缓冲液在pH 5.8条件下从DEAE - 纤维素洗脱的7S免疫球蛋白的第一部分中。该部分含有7Sγ1和7Sγ2免疫球蛋白，但未检测到γA、γM或皮肤致敏活性。仅含7Sγ2的部分在被动转移中无效。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ffd/1445755/df449d312019/immunology00312-0108-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ffd/1445755/df449d312019/immunology00312-0108-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ffd/1445755/df449d312019/immunology00312-0108-a.jpg

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Immunology. 1974 Aug;27(2):209-25.
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Activity of mouse reaginic antibodies in the rat: passive cutaneous anaphylaxis and in vitro passive histamine release.小鼠反应素抗体在大鼠体内的活性：被动皮肤过敏反应及体外被动组胺释放
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