各种实体瘤中癌细胞之间的低电阻连接。
Low-resistance junctions between cancer cells in various solid tumors.
作者信息
Sheridan J D
出版信息
J Cell Biol. 1970 Apr;45(1):91-9. doi: 10.1083/jcb.45.1.91.
Abstract
Electrical coupling, which reveals the presence of specialized low-resistance intercellular junctions, has now been found in four types of tumors, Sarcoma 180, Novikoff hepatoma, and Morris hepatomas 3924-A and 7777. Coupled cancer cells were distinguished from coupled normal cells by intracellular marking techniques. Although the evidence suggests that coupling may be extensive in some cases, it is not possible to say that the coupling was normal. In particular, the results do not exclude less obvious defects in the specialized junctions, such as abnormal distribution or decreased permeability to molecules other than small inorganic ions. The results are discussed in relation to previous studies of coupling in Novikoff hepatomas and in cultures of S1801 and II cell lines.
摘要
电耦合揭示了特殊低电阻细胞间连接的存在，目前已在四种肿瘤中发现，即肉瘤180、诺维科夫肝癌、莫里斯肝癌3924 - A和7777。通过细胞内标记技术区分了耦合的癌细胞和耦合的正常细胞。尽管有证据表明在某些情况下耦合可能广泛存在，但无法确定这种耦合是正常的。特别是，结果并未排除特殊连接中不太明显的缺陷，如异常分布或对除小无机离子以外的分子通透性降低。结合先前对诺维科夫肝癌以及S1801和II细胞系培养物中耦合的研究对结果进行了讨论。
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