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在猴子身上实现血脑屏障的渗透性开放且无相关神经功能缺损。

Osmotic opening of the blood-brain barrier in the monkey without associated neurological deficits.

作者信息

Rapoport S I, Thompson H K

出版信息

Science. 1973 Jun 1;180(4089):971. doi: 10.1126/science.180.4089.971.

DOI:10.1126/science.180.4089.971
PMID:4196324
Abstract

Hypertonic urea or lactamide solutions osmotically open the blood-brain barrier in the monkey without producing gross neurological deficits if the blood supply to the brain is not compromised. The brain is perfused via the left lingual artery when the external and common carotid arteries are clamped temporarily. Hypertonic perfusion, which opens the barrier by opening tight junctions between cerebrovascular endothelial cells, can thus be used to study barrier function and brain pharmacology.

摘要

高渗尿素或乳酰胺溶液可通过渗透作用打开猴子的血脑屏障，前提是脑供血不受影响，且不会产生明显的神经功能缺损。当颈外动脉和颈总动脉暂时夹闭时，通过左舌动脉对脑进行灌注。高渗灌注通过打开脑血管内皮细胞之间的紧密连接来打开屏障，因此可用于研究屏障功能和脑药理学。

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