人类对θX 174的免疫反应。I. 正常成年人的初次和二次抗体产生
The immune response to thetaX 174 in man. I. Primary and secondary antibody production in normal adults.
作者信息
Peacock D B, Jones J V, Gough M
出版信息
Clin Exp Immunol. 1973 Apr;13(4):497-513.
The bacteriophage [unk]X 174 has been administered intravenously in doses within the range 10–10 PFU to twenty-six normal human adult volunteers. Antibody was measured as a 50% bacteriophage neutralization titre (SD). Pre-immunization antibody was found in only one subject. All subjects showed a primary (IgM) response. Peak titres of antibody of 18–8000 occurred between days 6 and 9 in a group of early responders, and between days 14 and 24 in a late group. The secondary response was tested in twenty subjects and peak titres of 1400–50,000 were found in a single group, between days 6 and 13. Thirteen out of fourteen subjects receiving a secondary dose after 6 weeks showed a peak antibody titre between 11,000 and 50,000. The uniformity of the secondary response indicates that it will be a valuable clinical test of antibody-producing capacity.
噬菌体[未知]X 174已以10⁶ - 10¹⁰噬菌斑形成单位（PFU）的剂量静脉注射给26名正常成年人类志愿者。抗体以50%噬菌体中和滴度（标准差）来衡量。仅在一名受试者中发现了免疫前抗体。所有受试者均表现出初次（IgM）反应。一组早期反应者在第6天至第9天之间抗体峰值滴度为18 - 8000，晚期反应组则在第14天至第24天之间出现。对20名受试者进行了二次反应测试，在第6天至第13天之间的一个单一组中发现抗体峰值滴度为1400 - 50000。14名在6周后接受二次剂量的受试者中有13名抗体峰值滴度在11000至50000之间。二次反应的一致性表明它将是一项评估抗体产生能力的有价值的临床测试。
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