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1
The immune response to phichi174 in man. IV. Primary and secondary antibody production in patients with chronic lymphatic leukaemia.人类对噬菌体φX174的免疫反应。IV. 慢性淋巴细胞白血病患者的初次和二次抗体产生
Clin Exp Immunol. 1975 Jul;21(1):101-8.
2
The immune response to thetaX 174 in man. I. Primary and secondary antibody production in normal adults.人类对θX 174的免疫反应。I. 正常成年人的初次和二次抗体产生
Clin Exp Immunol. 1973 Apr;13(4):497-513.
3
Antibody response to bacteriophage theta-X 174 in vitro: demonstration of immunological memory in terms of IgM and IgG responses.体外针对噬菌体θ-X 174的抗体反应：根据IgM和IgG反应证明免疫记忆
Eur J Immunol. 1972 Aug;2(4):332-7. doi: 10.1002/eji.1830020407.
4
The recognition and classification of immunodeficiency diseases with bacteriophage phiChi 174.
Birth Defects Orig Artic Ser. 1975;11(1):331-8.
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Immune response to phi X 174 in man. 5. Primary and secondary antibody production in primary biliary cirrhosis.人类对φX 174的免疫反应。5. 原发性胆汁性肝硬化中的初次和二次抗体产生。
Gut. 1976 Nov;17(11):844-8. doi: 10.1136/gut.17.11.844.
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The immune response of phiX 174 in man. III. Evidence for an association between hyposplenism and immunodeficiency in patients with coeliac disease.人对φX 174的免疫反应。III. 乳糜泻患者脾功能减退与免疫缺陷之间关联的证据。
Gut. 1975 Jul;16(7):538-42. doi: 10.1136/gut.16.7.538.
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Mitogen-stimulated immunoglobulin production by chronic lymphocytic leukaemic lymphocytes.丝裂原刺激的慢性淋巴细胞白血病淋巴细胞的免疫球蛋白产生
Clin Exp Immunol. 1982 Mar;47(3):697-705.
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The immunoglobulin class responses to oral poliovaccine in coeliac disease.乳糜泻患者对口服脊髓灰质炎疫苗的免疫球蛋白类别反应。
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[Surface immunoglobulins of lymphocytes in chronic lymphocytic leukemia].[慢性淋巴细胞白血病中淋巴细胞的表面免疫球蛋白]
Acta Haematol Pol. 1976;7(1):23-30.
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Defective in vitro antibody production in response to pokeweed mitogen and influenza antigen in patients with Hodgkin's disease.霍奇金病患者对商陆丝裂原和流感抗原的体外抗体产生存在缺陷。
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Serum globulins as marker of immune restoration after treatment with high-dose rituximab for chronic lymphocytic leukemia.血清球蛋白作为大剂量利妥昔单抗治疗慢性淋巴细胞白血病后免疫恢复的标志物。
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2
Complement activation by malignant B cells from patients with chronic lymphocytic leukaemia (CLL).慢性淋巴细胞白血病（CLL）患者恶性B细胞的补体激活。
Clin Exp Immunol. 1995 Dec;102(3):575-81. doi: 10.1111/j.1365-2249.1995.tb03855.x.
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Detection and characterization of a novel bisegmented double-stranded RNA virus (picobirnavirus) from rabbit faeces.从兔粪便中检测和鉴定一种新型双节段双链RNA病毒（微小双股RNA病毒）。
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Clin Exp Immunol. 1989 Aug;77(2):239-44.
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Decreased expression of complement receptor type 2 (CR2) on neoplastic B cells of chronic lymphocytic leukaemia.慢性淋巴细胞白血病肿瘤性B细胞上2型补体受体（CR2）表达降低。
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Studies on the immune status of children with acute lymphocytic leukaemia. II. In remission with and without cytostatic treatment.急性淋巴细胞白血病患儿免疫状态的研究。II. 接受和未接受细胞抑制治疗的缓解期患儿。
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7
Restoration of "normal" membrane function in CLL cells by patients' serum.患者血清使慢性淋巴细胞白血病细胞的“正常”膜功能得以恢复。
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本文引用的文献

1
Quantitative antibody studies in man. II. The relation of the level of serum proteins to antibody production.人体定量抗体研究。II. 血清蛋白水平与抗体产生的关系。
J Lab Clin Med. 1952 Jan;39(1):129-33.
2
IMMUNOLOGICAL DEFICIENCY DISORDERS ASSOCIATED WITH CHRONIC LYMPHOCYTIC LEUKEMIA AND MULTIPLE MYELOMA.与慢性淋巴细胞白血病和多发性骨髓瘤相关的免疫缺陷疾病
J Clin Invest. 1964 Dec;43(12):2241-8. doi: 10.1172/JCI105098.
3
Circulating antibodies in reticuloses.网状细胞增多症中的循环抗体。
Lancet. 1961 Jun 17;1(7190):1305-10. doi: 10.1016/s0140-6736(61)90237-9.
4
Quantitative antibody studies in man. III. Antibody response in leukemia and other malignant lymphomata.人体定量抗体研究。III. 白血病及其他恶性淋巴瘤中的抗体反应。
J Clin Invest. 1953 Apr;32(4):317-21. doi: 10.1172/JCI102741.
5
Immunologic responses to bacteriophage phi-X 174 in immunodeficiency diseases.免疫缺陷疾病中对噬菌体phi-X 174的免疫反应。
J Clin Invest. 1971 Dec;50(12):2559-68. doi: 10.1172/JCI106756.
6
The immune response to thetaX 174 in man. I. Primary and secondary antibody production in normal adults.人类对θX 174的免疫反应。I. 正常成年人的初次和二次抗体产生
Clin Exp Immunol. 1973 Apr;13(4):497-513.

人类对噬菌体φX174的免疫反应。IV. 慢性淋巴细胞白血病患者的初次和二次抗体产生

The immune response to phichi174 in man. IV. Primary and secondary antibody production in patients with chronic lymphatic leukaemia.

作者信息

Hamblin T J, Jones J V, Peacock D B

出版信息

Clin Exp Immunol. 1975 Jul;21(1):101-8.

PMID:810280
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1538244/
Abstract

Ten patients with chronic lymphatic leukaemia (CLL) were injected with the antigen phichi174 intravenously on two occasions to test their capacity for antibody production. Nine out of ten patients failed to develop a primary response, and five out of ten failed to develop a secondary response. Only one out of the ten of the secondary responses fell within the normal range. There was evidence of defective switching from IgM to IgG antibody in two out of three cases in which the immunoglobulin class of antibody in the secondary response was determined. The severity of the immunoparesis in CLL is related to the severity of the disease.

摘要

十名慢性淋巴细胞白血病（CLL）患者分两次静脉注射噬菌体174抗原，以测试其产生抗体的能力。十名患者中有九名未能产生初次反应，十名中有五名未能产生二次反应。十名患者的二次反应中只有一名在正常范围内。在确定二次反应中抗体免疫球蛋白类别的三例病例中，有两例存在从IgM向IgG抗体转换缺陷的证据。CLL中免疫球蛋白缺乏症的严重程度与疾病的严重程度相关。