人类对噬菌体φX174的免疫反应。IV. 慢性淋巴细胞白血病患者的初次和二次抗体产生
The immune response to phichi174 in man. IV. Primary and secondary antibody production in patients with chronic lymphatic leukaemia.
作者信息
Hamblin T J, Jones J V, Peacock D B
出版信息
Clin Exp Immunol. 1975 Jul;21(1):101-8.
Abstract
Ten patients with chronic lymphatic leukaemia (CLL) were injected with the antigen phichi174 intravenously on two occasions to test their capacity for antibody production. Nine out of ten patients failed to develop a primary response, and five out of ten failed to develop a secondary response. Only one out of the ten of the secondary responses fell within the normal range. There was evidence of defective switching from IgM to IgG antibody in two out of three cases in which the immunoglobulin class of antibody in the secondary response was determined. The severity of the immunoparesis in CLL is related to the severity of the disease.
摘要
十名慢性淋巴细胞白血病（CLL）患者分两次静脉注射噬菌体174抗原，以测试其产生抗体的能力。十名患者中有九名未能产生初次反应，十名中有五名未能产生二次反应。十名患者的二次反应中只有一名在正常范围内。在确定二次反应中抗体免疫球蛋白类别的三例病例中，有两例存在从IgM向IgG抗体转换缺陷的证据。CLL中免疫球蛋白缺乏症的严重程度与疾病的严重程度相关。
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本文引用的文献
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J Lab Clin Med. 1952 Jan;39(1):129-33.
2
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J Clin Invest. 1964 Dec;43(12):2241-8. doi: 10.1172/JCI105098.
3
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Lancet. 1961 Jun 17;1(7190):1305-10. doi: 10.1016/s0140-6736(61)90237-9.
4
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J Clin Invest. 1953 Apr;32(4):317-21. doi: 10.1172/JCI102741.
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