厌氧棒状杆菌在特异性和非特异性免疫反应中的作用。II. 巨噬细胞特异性趋化因子的产生。
Role of anaerobic coryneforms in specific and non-specific immunological reactions. II. Production of a chemotactic factor specific for macrophages.
作者信息
Wilkinson P C, O'Neill G J, Wapshaw K G
出版信息
Immunology. 1973 Jun;24(6):997-1006.
Abstract
A chemotactic factor has been isolated from cultures and culture filtrates of many members of the group of anaerobic coryneform bacteria which includes various strains of . This factor attracts guinea-pig and mouse peritoneal exudate macrophages specifically and fails to attract either human blood neutrophils or guinea-pig peritoneal exudate neutrophils. Its activity is serum-independent. It is non-dialysable and destroyed by boiling. There is strong, positive correlation between the capacity of individual strains of anaerobic coryneforms to produce this macrophage chemotactic factor and the capacity of the same micro-organisms, when injected into mice, to enhance the clearance of carbon from the circulation.
摘要
已从厌氧棒状杆菌属细菌（包括各种菌株）的培养物和培养滤液中分离出一种趋化因子。该因子特异性地吸引豚鼠和小鼠腹腔渗出液巨噬细胞，而不吸引人类血液中性粒细胞或豚鼠腹腔渗出液中性粒细胞。其活性不依赖于血清。它不可透析，煮沸后会被破坏。厌氧棒状杆菌的各个菌株产生这种巨噬细胞趋化因子的能力与相同微生物注射到小鼠体内后增强循环中碳清除的能力之间存在强烈的正相关。
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