Moe H
Acta Pathol Microbiol Scand A. 1979 Jan;87(1):1-9. doi: 10.1111/j.1699-0463.1979.tb00016.x.
Secretory ameloblasts in the continuously growing incisors of the rat were used to study the sequential changes in a mature cell type degenerating after administration of vinblastine at a dosage of 2 mg per kg body weight. In less than half an hour nearly all microtubules vanished. This was succeeded by progressive displacement of the nuclei and disorganization of the cytoplasmic structure. After 1 to 3 hours attached and free polyribosomes were converted into monoribosomes. All these cytoplasmic changes were seen in viable as well as in necrotic cell. Between 5 and 61/2 hours after application of the drug degeneration of nuclei began; these changes from the outset indicated that a particular ameloblast had been drawn into a sequence of events which would ultimately lead to its death. The progressive alterations of the nucleus and cytoplasm of the degenerating cells and the concurrent fragmentation and elimination of the fragments are described.
在大鼠不断生长的切牙中，分泌性成釉细胞被用于研究在以每千克体重2毫克的剂量给予长春碱后，一种成熟细胞类型退化过程中的相继变化。在不到半小时内，几乎所有微管消失。随后是细胞核的逐渐移位和细胞质结构的紊乱。1至3小时后，附着的和游离的多核糖体转化为单核糖体。所有这些细胞质变化在活细胞和坏死细胞中均可见到。用药后5至6个半小时之间，细胞核开始退化；这些变化从一开始就表明，特定的成釉细胞已被卷入一系列最终会导致其死亡的事件中。本文描述了退化细胞的细胞核和细胞质的渐进性改变以及碎片的同时断裂和清除。
