Moe H, Mikkelsen H
Acta Pathol Microbiol Scand A. 1977 May;85(3):319-29. doi: 10.1111/j.1699-0463.1977.tb00432.x.
The effects of vinblastine sulphate at a dosage of 0.2 mg per 100 g body weight on the secretory ameloblasts of rat incisors were studied 3, 6 and 24 hours and 3 and 7 days after administration of the drug. The vinblastine affected the secretion profoundly, caused a reduction in size of the cells and death of many ameloblasts. Most of the surviving ameloblasts restored initially-induced loss of polarity. Many also resumed secretion and deposition of enamel matrix. The Tomes' processess were extremely sensitive to vinblastine and all matrix deposited after administration of the drug appeared abnormal in structure. Ameloblasts not resuming secretory activity were less than half the size (height) of normal cells. In some areas all the ameloblasts were destroyed with the exception of a varying number of surviving ameloblasts parts consisting only of a nucleus and a small amount of cytoplasm. The ameloblasts which had re-established secretory activity, and most of the ameloblasts which had not, retained their ability to transform into transporting ameloblasts. Large amounts of ameloblast debris present 3 and 6 hours after administration of the vinblastine were effectively engulfed and digested by the cells of the striatum intermedium within 24 hours.
研究了硫酸长春碱以每100克体重0.2毫克的剂量给药后3小时、6小时、24小时以及3天和7天对大鼠切牙分泌性成釉细胞的影响。长春碱对分泌有深远影响，导致细胞大小减小且许多成釉细胞死亡。大多数存活的成釉细胞恢复了最初诱导的极性丧失。许多细胞还恢复了釉质基质的分泌和沉积。托姆斯突对长春碱极为敏感，给药后沉积的所有基质在结构上都显得异常。未恢复分泌活性的成釉细胞大小（高度）不到正常细胞的一半。在某些区域，除了数量不等的仅由细胞核和少量细胞质组成的存活成釉细胞部分外，所有成釉细胞均被破坏。已重新建立分泌活性的成釉细胞以及大多数未重新建立分泌活性的成釉细胞保留了转化为运输性成釉细胞的能力。长春碱给药后3小时和6小时出现的大量成釉细胞碎片在24小时内被中间层纹状细胞有效吞噬和消化。
