Donati M B, Semeraro N, Vermylen J
J Clin Pathol. 1973 Oct;26(10):760-3. doi: 10.1136/jcp.26.10.760.
Fibrinogen antigens were measured either with an agglutination inhibition method (using latex particles coated with fibrinogen; Diagen test) or with a direct agglutination technique (using latex particles coated with a mixture of anti-D and anti-E antibodies; Thrombo-Wellcotest). Both methods were compared with the tanned red cell haemagglutination inhibition immunoassay (TRCHII) during progressive degradation of fibrinogen with plasmin and using purified fibrinogen fragments or urine concentrates from chronic glomerulonephritis or transplanted patients. Due to the different sensitivity of the two latex techniques to fibrinogen and its plasmin derivatives, their combined use may be helpful to distinguish the nature of the fibrinogen-like material excreted in urine.
纤维蛋白原抗原的测定方法有两种，一种是凝集抑制法（使用包被有纤维蛋白原的乳胶颗粒；Diagen试验），另一种是直接凝集技术（使用包被有抗-D和抗-E抗体混合物的乳胶颗粒；Thrombo-Wellcotest）。在纤维蛋白原被纤溶酶逐步降解的过程中，以及使用纯化的纤维蛋白原片段或慢性肾小球肾炎患者或移植患者的尿浓缩物时，将这两种方法与鞣酸红细胞血凝抑制免疫测定法（TRCHII）进行了比较。由于这两种乳胶技术对纤维蛋白原及其纤溶酶衍生物的敏感性不同，联合使用它们可能有助于区分尿中排泄的纤维蛋白原样物质的性质。
