Brueton M J, Breeze G R, Stuart J
J Clin Pathol. 1976 Apr;29(4):341-4. doi: 10.1136/jcp.29.4.341.
An increase in low molecular weight fibrin-fibrinogen degradation products (FDP) was demonstrated in cerebrospinal fluid (CSF) from 17 of 18 patients with bacterial or viral meningitis compared with 29 patients without meningitis. The CSF also showed an increase in coagulation proteins of molecular weight less than 90000 (factors VII, IX, and plasminogen) but did not contain fibrinogen (MW 340000) or plasminogen activator. It is concluded that low molecular weight FDP in the CSF in infective meningitis result from leakage through a damaged blood-CSF barrier rather than from local digestion of fibrin deposited on the meninges.
与29例无脑膜炎的患者相比，18例细菌性或病毒性脑膜炎患者中有17例的脑脊液（CSF）中低分子量纤维蛋白 - 纤维蛋白原降解产物（FDP）增加。脑脊液中分子量小于90000的凝血蛋白（因子VII、IX和纤溶酶原）也有所增加，但不含纤维蛋白原（分子量340000）或纤溶酶原激活物。结论是，感染性脑膜炎患者脑脊液中的低分子量FDP是由于受损的血脑屏障渗漏所致，而非脑膜上沉积的纤维蛋白的局部消化。
