使用不溶性人IgG测定类风湿疾病中的IgG抗球蛋白
Determination of IgG antiglobulins in rheumatoid disease using insolubilized human IgG.
作者信息
Ilter O D, Turner M W
出版信息
Clin Exp Immunol. 1973 Sep;15(1):93-101.
Abstract
IgG antiglobulins in human sera were measured by single radial diffusion in agar after elution from ethyl chloroformate insolubilized immunosorbents of rabbit or human IgG. With both immunosorbents seronegative and seropositive rheumatoid sera contained significantly higher levels of IgG antiglobulins than did sera from healthy adults. Attempts to measure antiglobulins interacting specifically with the pFc' half of the Fc region were not successful due to an unacceptably high degree of non-antibody binding.
摘要
在从兔或人IgG的氯甲酸乙酯不溶性免疫吸附剂上洗脱后，通过琼脂单向扩散法测定人血清中的IgG抗球蛋白。使用这两种免疫吸附剂时，类风湿血清阴性和血清阳性的血清中IgG抗球蛋白水平均显著高于健康成年人的血清。由于非抗体结合程度高得令人无法接受，因此未能成功测量与Fc区域pFc'半段特异性相互作用的抗球蛋白。
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