Natvig J B, Gaarder P I, Turner M W
Clin Exp Immunol. 1972 Oct;12(2):177-84.
Haemagglutination inhibition experiments were used to study the interaction of several well-defined rheumatoid factors with pFc' fragments (≡Cγ3 homology regions) prepared from all four IgG subclasses. The results suggest that rheumatoid factors interact with antigens located in both homology regions of the Fc fragment. A minimum of four reactive regions is suggested—one in the Cγ3 region and three more in the Cγ2 region. This multiplicity of IgG antigens may contribute to the formation of rheumatoid factor-IgG complexes and therefore play a role in the complement-fixing activity of such complexes.
血凝抑制实验用于研究几种明确的类风湿因子与从所有四种IgG亚类制备的pFc'片段（≡Cγ3同源区域）之间的相互作用。结果表明，类风湿因子与Fc片段两个同源区域中的抗原相互作用。提示至少有四个反应区域——一个在Cγ3区域，另外三个在Cγ2区域。IgG抗原的这种多样性可能有助于类风湿因子-IgG复合物的形成，因此在这类复合物的补体固定活性中发挥作用。
