Shakib F, Stanworth D R
Ann Rheum Dis. 1978 Feb;37(1):12-7. doi: 10.1136/ard.37.1.12.
A sensitive radioimmunoassay has been applied to the study of rheumatoid factor activity of IgM and IgG subclasses in serum and synovial fluid of patients with rheumatoid arthritis. Although rheumatoid factor activity was found in all four subclasses, its distribution was not the same as that of the total subclasses in normal sera. Results are discussed in relation to the possible clinical value of measuring IgG rheumatoid factor in sera and synovial fluids of patients with rheumatoid arthritis.
一种灵敏的放射免疫分析法已应用于研究类风湿性关节炎患者血清和滑液中IgM和IgG亚类的类风湿因子活性。虽然在所有四个亚类中均发现有类风湿因子活性,但其分布与正常血清中总亚类的分布不同。本文结合测定类风湿性关节炎患者血清和滑液中IgG类风湿因子的可能临床价值对结果进行了讨论。