萘夫西林、苯唑西林和甲氧西林联合庆大霉素及妥布霉素对肠球菌的体外比较活性
Comparative in vitro activity of nafcillin, oxacillin, and methicillin in combination with gentamicin and tobramycin against enterococci.
作者信息
Watanakunakorn C, Glotzbecker C
出版信息
Antimicrob Agents Chemother. 1977 Jan;11(1):88-91. doi: 10.1128/AAC.11.1.88.
The in vitro activity of nafcillin, oxacillin, and methicillin alone and in combination with gentamicin and tobramycin against 30 strains of enterococci was investigated. The penicillinase-resistant penicillins were less active than penicillin and ampicillin against the enterococci. Nafcillin was more active than oxacillin and methicillin. Sixty-six percent of strains were inhibited by nafcillin at 6.25 mug/ml, but none was inhibited by oxacillin and methicillin at the same concentration. At 12.5 mug/ml, 83, 16, and 0% were inhibited by nafcillin, oxacillin, and methicillin, respectively. By using a variety of criteria and analyses, it was shown that none of the antibiotic combinations studied demonstrated enhanced killing of all strains of enterococci. Nafcillin-gentamicin was the best combination, and enhanced killing was demonstrated against most strains. Oxacillin was more effective than methicillin when combined with gentamicin. Tobramycin was probably less effective than gentamicin in combination with the penicillinase-resistant penicillins against enterococci.
研究了萘夫西林、苯唑西林和甲氧西林单独以及与庆大霉素和妥布霉素联合对30株肠球菌的体外活性。耐青霉素酶的青霉素类药物对肠球菌的活性低于青霉素和氨苄西林。萘夫西林比苯唑西林和甲氧西林更具活性。66%的菌株在6.25μg/ml的萘夫西林作用下受到抑制，但在相同浓度下，苯唑西林和甲氧西林均未抑制任何菌株。在12.5μg/ml时，萘夫西林、苯唑西林和甲氧西林分别抑制83%、16%和0%的菌株。通过多种标准和分析表明，所研究的抗生素组合均未显示出对所有肠球菌菌株的杀菌作用增强。萘夫西林-庆大霉素是最佳组合，对大多数菌株显示出杀菌作用增强。苯唑西林与庆大霉素联合时比甲氧西林更有效。妥布霉素与耐青霉素酶的青霉素类药物联合用于肠球菌时可能不如庆大霉素有效。
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