Rekhtman M B, Konnikov B A, Kryzhanovskiĭ G N
Biull Eksp Biol Med. 1979 Feb;87(2):160-4.
Chronic experiments were conducted on rats. A study was made of the effect of diazepam (in a dose of 4 mg/kg of body weight) on the specific and nonspecific mechanisms of experimentally-induced photogenic epilepsy developing as a result of tetanus toxin injection into the lateral geniculate body (LGB) and formation in this nucleus of a pathologically enhanced excitation generator (PEEG). Diazepam in the mentioned dose had a relatively weak effect on the extent of pathological enhancement of the sensory visual signal in the LGB under conditions of PEEG formation aided detection of focal interictal discharges in this nucleus, and completely inhibited generalized epileptic activity in experimental animals in the course of one hour.
对大鼠进行了慢性实验。研究了地西泮（剂量为4毫克/千克体重）对实验性光源性癫痫的特异性和非特异性机制的影响，该癫痫是由于向外侧膝状体（LGB）注射破伤风毒素并在该核中形成病理性增强的兴奋发生器（PEEG）而引发的。在PEEG形成并有助于检测该核中的局灶性发作间期放电的情况下，上述剂量的地西泮对LGB中感觉视觉信号病理性增强的程度影响相对较弱，但在一小时内完全抑制了实验动物的全身性癫痫活动。
