Konnikov B A, Rekhtman M B, Kryzhanovskiĭ G N
Biull Eksp Biol Med. 1979 Jan;87(1):8-12. doi: 10.1007/BF00802340.
Male albino rats were used in chronic experiments. The photogenic epilepsy syndrome was induced by local tetanus toxin injection into the lateral geniculate blody (LGB) which caused the formation of a pathologically enhanced excitation. The primary symptoms of photogenic epilepsy resulted from the pathologically enhanced specific sensory excitation in the LGB, and correlated with a significant increase of the evoked potential amplitude in the corresponding visual cortex field. The following progress of the neuropathological syndrome was connected with generalized disturbances of the rhythmic electrical activity of the brain, characterizing the state of increased epileptic sensibility. The experimental results demonstrate an important role of specific and nonspecific factors in the pathogenesis of experimental photogenic epilepsy.
雄性白化大鼠用于慢性实验。通过向外侧膝状体（LGB）局部注射破伤风毒素诱发光原性癫痫综合征，这导致了病理性增强的兴奋形成。光原性癫痫的主要症状源于LGB中病理性增强的特定感觉兴奋，并与相应视觉皮层区域诱发电位幅度的显著增加相关。神经病理综合征的以下进展与大脑节律性电活动的全身性紊乱有关，这表征了癫痫易感性增加的状态。实验结果证明了特异性和非特异性因素在实验性光原性癫痫发病机制中的重要作用。
