Kryzhanovskii G N, Konnikov B A, Rekhtman M B
Zh Nevropatol Psikhiatr Im S S Korsakova. 1979;79(6):720-5.
Chronic experiments on rats permitted one to obtain an experimental model of photogenic epilepsy. This was accomplished by creating in the external geniculate body (EGB) a generator of pathologically intensified excitation (GPIE) with the aid of tetanus toxin (TT). According to some clinical and electrographic characteristics this form of epilepsy may be alloted to the type of primarily generalized or "genuine" epilepsy. The existance of focal pathology in the respective EGB was detected only by special electrophysiological and pharmacological methods. The studied model demonstrates a necessity of using special methods of detecting brain focal pathology (GPIE) in order to determine the focus of neuron hyperactivity in those cases where the clinical picture is characterized by signs of the so-called genuine epilepsy. Experimental photogenic epilepsy attained by creating GPIE in the EGB with the aid of TT, is proposed as a model for studying the mechanism of epileptogenesis and testing the efficacy of anticonvulsive drugs.
对大鼠进行的慢性实验使人们能够获得光源性癫痫的实验模型。这是通过借助破伤风毒素（TT）在外侧膝状体（EGB）中创建一个病理性增强兴奋的发生器（GPIE）来实现的。根据一些临床和脑电图特征，这种癫痫形式可归为原发性全身性或“真性”癫痫类型。仅通过特殊的电生理和药理学方法才能检测到相应EGB中的局灶性病变。所研究的模型表明，在临床症状以所谓真性癫痫体征为特征的情况下，有必要使用特殊方法来检测脑局灶性病变（GPIE），以确定神经元活动亢进的病灶。借助TT在EGB中创建GPIE所获得的实验性光源性癫痫，被提议作为研究癫痫发生机制和测试抗惊厥药物疗效的模型。
