Shearn A
Genetics. 1974 May;77(1):115-25. doi: 10.1093/genetics/77.1.115.
Late larval and pupal lethal mutants of Drosophila define those gene functions which are essential for the development of pupae (metamorphosis) but not for embryonic or larval development. In a previous report the isolation of a large number of such mutants was outlined, and a description of the imaginal disc defects in those mutants was described. This report concerns genetic analysis of those mutants. 3746 different pairwise combinations of mutants have been tested for complementation. Only 10 pairs fail to complement. In all of the cases tested, the lethal mutation in each member of a non-complementing pair has a similar map location. In addition to the non-complementing pairs one group of seven partially-complementing mutants has been identified. Comparisons of the imaginal disc defects within the non-complementing pairs and the lethal hybrids formed by the respective pairs were made to test for uniformity of phenotype. No significant qualitative differences were detected between any non-complementing pairs or their respective hybrids.
果蝇的晚期幼虫和蛹期致死突变体定义了那些对蛹发育（变态）至关重要但对胚胎或幼虫发育并非必需的基因功能。在之前的一份报告中概述了大量此类突变体的分离情况，并描述了这些突变体中 imaginal disc 的缺陷。本报告涉及对这些突变体的遗传分析。已经对 3746 种不同的突变体两两组合进行了互补测试。只有 10 对不能互补。在所有测试的案例中，非互补对中每个成员的致死突变具有相似的图谱位置。除了非互补对外，还鉴定出一组七个部分互补的突变体。对非互补对内的 imaginal disc 缺陷以及由各自配对形成的致死杂种进行了比较，以测试表型的一致性。在任何非互补对或其各自的杂种之间未检测到明显的定性差异。
