负责在兔肺中引发慢性免疫炎症反应的分枝杆菌成分。
Mycobacterial components responsible for the induction of a chronic immunological inflammatory response in rabbit lungs.
作者信息
Moore V L, Myrvik Q N
出版信息
Infect Immun. 1974 Jul;10(1):21-4. doi: 10.1128/iai.10.1.21-24.1974.
Abstract
Fractions of the tubercle bacillus were examined for their capacity to produce an allergic pulmonary granulomatous response in rabbits. We found that emulsions containing old tuberculin and even old tuberculin alone in an emulsion could induce a pulmonary inflammatory reaction comparable in intensity to that produced with killed BCG. Emulsions lacking old tuberculin failed to produce an allergic pulmonary inflammatory response. The significance of these results in relation to immunological and nonimmunological chronic inflammation is discussed.
摘要
对结核杆菌的各个部分进行了检测，以观察它们在兔体内引发过敏性肺肉芽肿反应的能力。我们发现，含有旧结核菌素的乳剂，甚至仅含旧结核菌素的乳剂，都能引发一种强度与用灭活卡介苗引发的反应相当的肺部炎症反应。缺乏旧结核菌素的乳剂未能引发过敏性肺部炎症反应。本文讨论了这些结果在免疫性和非免疫性慢性炎症方面的意义。
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本文引用的文献
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Effect of antimacrophage serum on dermal tuberculin sensitivity and allergic pulmonary granuloma formation in rabbits.抗巨噬细胞血清对兔皮肤结核菌素敏感性和过敏性肺肉芽肿形成的影响。
Infect Immun. 1970 Dec;2(6):810-4. doi: 10.1128/iai.2.6.810-814.1970.
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Chemical factors involved in the induction of infectious allergy.诱导感染性过敏所涉及的化学因素。
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Changes in morphology and in lysozyme content of free alveolar cells after the intravenous injection of killed BCG in oil.静脉注射油剂灭活卡介苗后游离肺泡细胞形态及溶菌酶含量的变化
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Migratory response of granulomatous alveolar cells from BCG-sensitized rabbits.卡介苗致敏兔的肉芽肿性肺泡细胞的游走反应。
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Role of adjuvants in the production of delayed hypersensitivity.佐剂在迟发型超敏反应产生中的作用。
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Granuloma formation induced in mice by chemically defined mycobacterial fractions.化学定义的分枝杆菌组分在小鼠中诱导形成肉芽肿。
J Bacteriol. 1969 Oct;100(1):95-102. doi: 10.1128/jb.100.1.95-102.1969.
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Acute granulomatous response produced in mice by trehalose-6,6-dimycolate.海藻糖-6,6-二霉菌酸酯在小鼠体内产生的急性肉芽肿反应。
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