用分枝杆菌的特定成分及一些无关物质诱导小鼠对结核病产生抗性。
Induction of resistance to tuberculosis in mice with defined components of mycobacteria and with some unrelated materials.
作者信息
Ribi E, Granger D L, Milner K C, Yamamoto K, Strain S M, Parker R, Smith R W, Brehmer W, Azuma I
出版信息
Immunology. 1982 Jun;46(2):297-305.
Abstract
Factors contributing to protection against experimental tuberculosis have been studied with refined and well characterized fractions from mycobacteria and with certain unrelated antigens. Mice were vaccinated intravenously with various combinations of materials presented on minute oil droplets in saline emulsions and were later challenged by aerosol. The minimal composition of an effective vaccine was P3 (a trehalose mycolate similar to cord factor) plus an antigen, which could be tuberculoprotein, or a low-molecular-weight tuberculin-active peptide, or unrelated antigen such as bovine serum albumin or bacterial endotoxin. Development of a hypersensitivity granuloma in the lungs appeared to be essential to protection in this laboratory model.
摘要
研究人员使用来自分枝杆菌的精制且特征明确的组分以及某些不相关的抗原来研究有助于预防实验性结核病的因素。将小鼠通过静脉注射接种于盐溶液乳剂中的微小油滴上呈现的各种材料组合，随后通过气溶胶进行攻击。有效疫苗的最小组成是P3（一种类似于索状因子的海藻糖霉菌酸酯）加一种抗原，该抗原可以是结核蛋白、低分子量结核菌素活性肽或不相关抗原，如牛血清白蛋白或细菌内毒素。在这个实验室模型中，肺部超敏性肉芽肿的形成似乎对保护至关重要。
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