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Enhancement of the IgG antibody production to Escherichia coli O antigen by prior exposure to serologically different E. coli bacteria.通过预先接触血清学上不同的大肠杆菌来增强对大肠杆菌O抗原的IgG抗体产生。
Immunology. 1974 Jan;26(1):67-76.
2
The primary and secondary antibody response to Escherichia coli O6 lipopolysaccharide analysed at the humoral and cellular level. Amount and avidity of the antibodies in relation to protective capacity.在体液和细胞水平分析对大肠杆菌O6脂多糖的初次和二次抗体反应。抗体的数量和亲和力与保护能力的关系。
Immunology. 1973 Feb;24(2):191-202.
3
Alteration of the antibody response to Escherichia coli O antigen in mice by prior exposure to various somatic antigens.小鼠先前接触各种菌体抗原后对大肠杆菌O抗原抗体反应的改变。
Immunology. 1975 Sep;29(3):487-96.
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The employment of the bactericidal and haemolytic plaque method for detection of 19S and 7S antibody-producing cells against somatic antigen of E. coli 086 in the primary response in rabbits.采用杀菌和溶血空斑法检测兔初次免疫应答中针对大肠杆菌086菌体抗原产生19S和7S抗体的细胞。
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引用本文的文献

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Immunology. 1975 May;28(5):841-6.
2
Antigen presentation as a factor in the protective immune response to renal infection.抗原呈递作为肾脏感染保护性免疫反应的一个因素。
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3
Alteration of the antibody response to Escherichia coli O antigen in mice by prior exposure to various somatic antigens.小鼠先前接触各种菌体抗原后对大肠杆菌O抗原抗体反应的改变。
Immunology. 1975 Sep;29(3):487-96.

本文引用的文献

1
Studies on the O antigen of Salmonella typhosa. V. Enhancement of antibody response to protein antigens by the purified lipopolysaccharide.伤寒沙门氏菌O抗原的研究。V. 纯化脂多糖增强对蛋白质抗原的抗体反应。
J Exp Med. 1956 Feb 1;103(2):225-46. doi: 10.1084/jem.103.2.225.
2
Immunodiffusion studies on Escherichia coli. 1. Identification of O, K and H antigens in an O6 strain.大肠杆菌的免疫扩散研究。1. 一株O6菌株中O、K和H抗原的鉴定。
Acta Pathol Microbiol Scand. 1969;76(2):304-18.
3
The antibody response in rabbits to E. coli O antigen.兔子对大肠杆菌O抗原的抗体反应。
Int Arch Allergy Appl Immunol. 1970;37(5):546-59. doi: 10.1159/000230242.
4
Cellular mechanisms of adjuvant action of bacterial lipopolysaccharide in anti-sheep red blood cell antibody response.细菌脂多糖在抗绵羊红细胞抗体应答中辅助作用的细胞机制
Jpn J Microbiol. 1971 Mar;15(2):149-58. doi: 10.1111/j.1348-0421.1971.tb00564.x.
5
Studies on the regulation of avidity at the level of the single antibody-forming cell. The effect of antigen dose and time after immunization.关于单个抗体形成细胞水平亲和力调节的研究。抗原剂量和免疫后时间的影响。
J Exp Med. 1970 Jul 1;132(1):77-88. doi: 10.1084/jem.132.1.77.
6
Immunodiffusion studies on Escherichia coli. 2. Characterization of antigens used for passive haemagglutination with an O 6 strain as model.大肠杆菌的免疫扩散研究。2. 以O6菌株为模型对用于被动血凝反应的抗原进行特性分析。
Acta Pathol Microbiol Scand. 1969;77(4):727-38.
7
Endotoxins and the immune response.内毒素与免疫反应。
Curr Top Microbiol Immunol. 1969;47:82-124. doi: 10.1007/978-3-642-46160-6_5.
8
The primary and secondary antibody response to Escherichia coli O6 lipopolysaccharide analysed at the humoral and cellular level. Amount and avidity of the antibodies in relation to protective capacity.在体液和细胞水平分析对大肠杆菌O6脂多糖的初次和二次抗体反应。抗体的数量和亲和力与保护能力的关系。
Immunology. 1973 Feb;24(2):191-202.
9
Induction of immunoglobulin and antibody synthesis in vitro by lipopolysaccharides.脂多糖在体外诱导免疫球蛋白和抗体合成
Eur J Immunol. 1972 Aug;2(4):349-53. doi: 10.1002/eji.1830020410.
10
Enzyme-linked immunosorbent assays for cholera serology.用于霍乱血清学的酶联免疫吸附测定
Infect Immun. 1973 May;7(5):759-63. doi: 10.1128/iai.7.5.759-763.1973.

通过预先接触血清学上不同的大肠杆菌来增强对大肠杆菌O抗原的IgG抗体产生。

Enhancement of the IgG antibody production to Escherichia coli O antigen by prior exposure to serologically different E. coli bacteria.

作者信息

Holmgren J, Ahlstedt S

出版信息

Immunology. 1974 Jan;26(1):67-76.

PMID:4210595
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1423118/
Abstract

Exposure of rabbits and mice to serologically different bacteria enhanced the synthesis of IgG but often suppressed the formation of IgM O antibodies in response to subsequent immunization with O6 bacteria. The effect differed with the O antigen used. A higher enhancing effect on the IgG antibody synthesis was associated with less suppression of the IgM-antibody formation. The antibody avidity of both immunoglobulin classes was relatively low compared to that in the ordinary immune response to O6. The findings indicated an enhancing action of endotoxin on the IgG antibody response to the O6 antigen.

摘要

将兔子和小鼠暴露于血清学不同的细菌中，可增强IgG的合成，但在随后用O6细菌免疫时，通常会抑制IgM O抗体的形成。这种效应因所用的O抗原而异。对IgG抗体合成的增强作用越大，对IgM抗体形成的抑制作用就越小。与对O6的普通免疫反应相比，这两类免疫球蛋白的抗体亲和力相对较低。这些发现表明内毒素对针对O6抗原的IgG抗体反应具有增强作用。