Pye I F, McGale E H, Stonier C, Hutchinson E C, Aber G M
Clin Chim Acta. 1979 Feb 15;92(1):65-72. doi: 10.1016/0009-8981(79)90397-8.
The concentration of free amino acids in the plasma and lumbar CSF of 11 patients with steady-state chronic renal failure has been measured and the CSF: plasma concentration ratios calculated. The results have been compared with the corresponding data from 37 control subjects. In renal failure, elevation of the mean plasma concentration of total amino acids and a reduction in the ratio of essential to total amino acids have been found. Whereas some individual plasma amino acid concentrations in renal failure were higher than normal, others were lower. Striking abnormalities of the CSF amino acid concentration have been observed. Some amino acids have shown similar patterns of abnormality in both CSF and plasma, whereas in the case of others, the changes have been restricted to either CSF or plasma. Significant variations from normal of the CSF: plasma concentration ratios were observed for four amino acids.
对11例稳定期慢性肾衰竭患者的血浆和腰椎脑脊液中的游离氨基酸浓度进行了测定，并计算了脑脊液与血浆的浓度比。将结果与37名对照受试者的相应数据进行了比较。在肾衰竭患者中，发现总氨基酸的平均血浆浓度升高，必需氨基酸与总氨基酸的比例降低。虽然肾衰竭患者的一些个体血浆氨基酸浓度高于正常水平，但其他的则较低。已观察到脑脊液氨基酸浓度存在显著异常。一些氨基酸在脑脊液和血浆中显示出相似的异常模式，而对于其他氨基酸，变化仅限于脑脊液或血浆。观察到四种氨基酸的脑脊液与血浆浓度比与正常水平有显著差异。
