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1
Temperature-induced changes in the sporicidal activity and chemical properties of glutaraldehyde.温度诱导的戊二醛杀菌活性和化学性质的变化。
Appl Microbiol. 1974 Sep;28(3):331-5. doi: 10.1128/am.28.3.331-335.1974.
2
Sporicidal action of alkaline glutaraldehyde: factors influencing activity and a comparison with other aldehydes.
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3
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4
Sensitivity and resistance to glutaraldehyde of the hydrogen and calcium forms of Bacillus pumilus spores.
J Appl Bacteriol. 1975 Jun;38(3):315-7. doi: 10.1111/j.1365-2672.1975.tb00536.x.
5
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6
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Alkali-induced revival of Bacillus spores after inactivation by glutaraldehyde.戊二醛灭活后碱诱导芽孢杆菌孢子复苏
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本文引用的文献

1
Biocidal activities of glutaraldehyde and related compounds.戊二醛及相关化合物的杀菌活性。
J Appl Bacteriol. 1967 Apr;30(1):78-87. doi: 10.1111/j.1365-2672.1967.tb00277.x.
2
The reactions between glutaraldehyde and various proteins. An investigation of their kinetics.戊二醛与各种蛋白质之间的反应。对其动力学的研究。
Histochem J. 1970 Mar;2(2):137-50. doi: 10.1007/BF01003541.
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Glutaraldehyde: nature of the reagent.戊二醛：试剂的性质。
J Mol Biol. 1972 Apr 14;65(3):525-9. doi: 10.1016/0022-2836(72)90206-9.
4
Ultrasonic synergistic effects in liquid-phase chemical sterilization.液相化学杀菌中的超声协同效应。
Appl Microbiol. 1971 Aug;22(2):160-4. doi: 10.1128/am.22.2.160-164.1971.
5
Aspects of the action of glutaraldehyde on Escherichia coli.戊二醛对大肠杆菌的作用方面。
J Appl Bacteriol. 1970 Jun;33(2):410-9. doi: 10.1111/j.1365-2672.1970.tb02214.x.
6
Chemical sterilizers (chemosterilizers).
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[Bactericidal properties of glutaraldehydes].[戊二醛的杀菌特性]
Pharm Weekbl. 1973 Mar 2;108(9):169-73.
8
Effect of glutaraldehyde on the outer layers of Escherichia coli.
J Appl Bacteriol. 1972 Jun;35(2):193-9. doi: 10.1111/j.1365-2672.1972.tb03690.x.
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Interaction of glutaraldehyde with spheroplasts of Escherichia coli.
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温度诱导的戊二醛杀菌活性和化学性质的变化。

Temperature-induced changes in the sporicidal activity and chemical properties of glutaraldehyde.

作者信息

Thomas S, Russell A D

出版信息

Appl Microbiol. 1974 Sep;28(3):331-5. doi: 10.1128/am.28.3.331-335.1974.

DOI:10.1128/am.28.3.331-335.1974
PMID:4213869
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC186719/
Abstract

Freshly prepared 2% acid and alkaline glutaraldehyde solutions were stored at 4, 20, and 37 C. At intervals, samples were removed and changes in pH, ultraviolet spectrum, and sporicidal activity (against Bacillus pumilus spores) were recorded. Alkaline solutions stored at 4 C showed little changes in these properties, whereas such solutions stored at 37 C became turbid and showed a decrease in pH, marked changes in ultraviolet spectrum, and an almost complete loss of sporicidal activity. Intermediate results were obtained with alkaline solutions stored at 20 C. In contrast, acid 2% glutaraldehyde solutions (initial pH 3.5) showed comparatively few changes in their properties. Treatment of spores with freshly prepared glutaraldehyde solutions (0.5%) at temperature above 40 C reduced the effect of pH on sporicidal activity.

摘要

新配制的2%酸性和碱性戊二醛溶液分别储存在4℃、20℃和37℃。每隔一段时间取出样品，记录pH值、紫外光谱和杀孢子活性（针对短小芽孢杆菌孢子）的变化。储存在4℃的碱性溶液在这些特性上变化很小，而储存在37℃的此类溶液变得浑浊，pH值降低，紫外光谱有明显变化，杀孢子活性几乎完全丧失。储存在20℃的碱性溶液得到的是中间结果。相比之下，2%酸性戊二醛溶液（初始pH值3.5）的特性变化相对较少。在40℃以上的温度下，用新配制的戊二醛溶液（0.5%）处理孢子可降低pH值对杀孢子活性的影响。