Rowan A J, Rudolf N de M, Scott D F
J Neurol Neurosurg Psychiatry. 1974 Aug;37(8):888-93. doi: 10.1136/jnnp.37.8.888.
A retrospective study comparing the EEG findings of two groups of patients with primary systemic malignant disease (mainly bronchial carcinoma) was carried out. One group of 13 patients (20 EEGs) had proven supratentorial cerebral metastases at necropsy, some also subtentorial, and the other group of 10 patients (15 EEGs) had no cerebral involvement at necropsy. The latter group was studied to assess the possible confusing effects in the EEG of metabolic derangements and other factors which would interfere with accurate prediction of the presence of metastases. The EEGs were masked and assessed independently by two raters using a special proforma. They found that recordings from patients with cerebral metastases had persistent focal delta activity, intermittent focal or local delta activity, persistent or intermittent lateralized delta activity, monorhythmic frontal delta activity in the alert patient, as well as a higher frequency of post-central background rhythms. These factors predicted the presence of cerebral metastases (when they were 2 cm in diameter or larger) in 12 out of the 13 patients (four of these without localized neurological disorder), the EEGs being taken on average eight weeks before death. It is concluded that the EEG is valuable in the investigation of these patients.
开展了一项回顾性研究，比较两组原发性全身性恶性疾病（主要为支气管癌）患者的脑电图（EEG）检查结果。一组13例患者（20份EEG记录）尸检证实幕上脑转移，部分患者也有幕下转移；另一组10例患者（15份EEG记录）尸检时无脑部受累。研究后一组患者是为了评估代谢紊乱及其他因素对EEG可能产生的混淆影响，这些因素会干扰对转移灶存在情况的准确预测。EEG记录进行了盲法处理，由两名评估者使用专用表格独立评估。他们发现，脑转移患者的记录存在持续性局灶性δ活动、间歇性局灶或局部δ活动、持续性或间歇性偏侧化δ活动、清醒患者的单节律额叶δ活动，以及中央后背景节律频率较高。这些因素在13例患者中的12例（其中4例无局限性神经功能障碍）中预测了脑转移灶（直径2厘米或更大）的存在，EEG记录平均在死亡前8周进行。得出的结论是，EEG在这些患者的检查中具有重要价值。
