• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

苯巴比妥处理的大鼠缺血肝脏中蛋白质合成的抑制作用

Inhibition of protein synthesis in ischaemic liver from phenobarbitone-treated rat.

作者信息

Ragnotti G, Aletti M G, Presta M

出版信息

Experientia. 1979 Jan 15;35(1):86-8. doi: 10.1007/BF01917894.

DOI:10.1007/BF01917894
PMID:421808
Abstract

Both ribosomal factors and cytosolic inhibitors are involved in the reduction of the rate of protein synthesis which occurs in the ischaemic hepatocyte from control and phenobarbitone-treated livers. Of these 2 factors it is the latter which seems to play a major role in determining the irreversible impairment of protein synthesis. Phenobarbitone administration has no effect on the rate of protein synthesis of ischaemic and post-ischaemic hepatocyte.

摘要

核糖体因子和胞质抑制剂都参与了蛋白质合成速率的降低,这种降低发生在来自对照和苯巴比妥处理肝脏的缺血肝细胞中。在这两种因素中,似乎是后者在决定蛋白质合成的不可逆损伤方面起主要作用。给予苯巴比妥对缺血和缺血后肝细胞的蛋白质合成速率没有影响。

相似文献

1
Inhibition of protein synthesis in ischaemic liver from phenobarbitone-treated rat.苯巴比妥处理的大鼠缺血肝脏中蛋白质合成的抑制作用
Experientia. 1979 Jan 15;35(1):86-8. doi: 10.1007/BF01917894.
2
Phenobarbitone-induced stimulation of protein synthesis in liver of diabetic rat.
Biochim Biophys Acta. 1978 Nov 21;521(1):352-62. doi: 10.1016/0005-2787(78)90277-0.
3
Effect of phenobarbitone on the nucleocytoplasmic transport of ribonucleic acid in vitro.苯巴比妥对体外核糖核酸核质转运的影响。
Biochem J. 1976 Jun 15;156(3):665-70. doi: 10.1042/bj1560665.
4
Liver cytosolic protein-bound folates in phenobarbitone-treated rats.苯巴比妥处理大鼠肝脏胞质中蛋白质结合型叶酸
Int J Vitam Nutr Res. 1987;57(4):405-9.
5
The effect of phenobarbitone on protein synthesis by liver polyribosomes in fed and starved rats.苯巴比妥对喂食及饥饿大鼠肝脏多核糖体蛋白质合成的影响。
Biochem J. 1975 Jan;146(1):1-12. doi: 10.1042/bj1460001.
6
Effects of amino acids on protein synthesis by cellular and subcellular preparations from ischaemic livers.氨基酸对缺血肝脏细胞及亚细胞制剂蛋白质合成的影响。
Br J Exp Pathol. 1974 Dec;55(6):575-82.
7
Protein synthesis in liver injury. Soluble factors of protein synthesis in the cytosol from ischemic rat liver.肝损伤中的蛋白质合成。缺血大鼠肝脏胞质溶胶中蛋白质合成的可溶性因子。
Lab Invest. 1976 Apr;34(4):387-93.
8
[Effect of phenobarbital on the protein synthesizing system of rat liver].
Naunyn Schmiedebergs Arch Exp Pathol Pharmakol. 1968;260(2):123-4.
9
Effect of coumarin and other compounds on ribosomal protein synthesis in the rat liver.
Nature. 1968 Aug 24;219(5156):858-60. doi: 10.1038/219858a0.
10
Effect of coumarin, BHT and phenobarbitone on protein synthesis in the rat liver.
Food Cosmet Toxicol. 1969 Nov;7(6):621-34. doi: 10.1016/s0015-6264(69)80464-5.

本文引用的文献

1
Effect of cycloheximide on protein biosynthesis in rat liver.环己亚胺对大鼠肝蛋白质生物合成的影响。
Biochem J. 1966 Dec;101(3):627-31. doi: 10.1042/bj1010627.
2
A simple plaque-inhibition test for the study of arthropod-borne viruses.一种用于研究节肢动物传播病毒的简单蚀斑抑制试验。
Bull World Health Organ. 1960;22(3-4):373-80.
3
SOME ASPECTS OF GLYCOGEN METABOLISM FOLLOWING REVERSIBLE OR IRREVERSIBLE LIVER ISCHEMIA.可逆性或不可逆性肝脏缺血后糖原代谢的某些方面
Exp Mol Pathol. 1964 Aug;3:351-68. doi: 10.1016/0014-4800(64)90007-3.
4
Protein synthesis in growing rat tissues. I. Effect of various metabolites and inhibitors on phenylalanine incorporation by brain and liver ribosomes.生长中大鼠组织的蛋白质合成。I. 各种代谢物和抑制剂对脑和肝核糖体掺入苯丙氨酸的影响。
Biochim Biophys Acta. 1966 Jun 22;119(3):586-98.
5
Studies on the mechanism of drug-induced microsomal enzyme activities. V. Phenobarbital stimulation of endogenous messenger RNA and polyuridylic acid-directed L-[14C]-phenylalanine incorporation.药物诱导微粒体酶活性机制的研究。V. 苯巴比妥对内源信使核糖核酸和多聚尿苷酸指导的L-[14C] -苯丙氨酸掺入的刺激作用
Mol Pharmacol. 1966 Mar;2(2):171-86.
6
Microsome-specific stimulation by phenobarbital of amino acid incorporation in vivo.苯巴比妥对体内氨基酸掺入的微粒体特异性刺激作用。
Biochem Pharmacol. 1965 Jul;14(7):1164-6. doi: 10.1016/0006-2952(65)90047-x.
7
Studies on the nature of polysomes.多核糖体性质的研究。
Biochem J. 1964 Aug;92(2):289-99. doi: 10.1042/bj0920289.
8
The effect of age on protein synthesis in mouse liver.年龄对小鼠肝脏蛋白质合成的影响。
Biochem J. 1969 Aug;113(5):869-78. doi: 10.1042/bj1130869.
9
Modification of the in vitro amino acid incorporation capacity of rat liver after in vivo and in vitro treatments.
Eur J Biochem. 1968 Mar;4(1):87-94. doi: 10.1111/j.1432-1033.1968.tb00176.x.
10
Studies on the mechanism of the inhibition of protein synthesis induced by intracellular ATP depletion.细胞内ATP耗竭诱导蛋白质合成抑制机制的研究。
Biochim Biophys Acta. 1971 Mar 25;232(3):537-55. doi: 10.1016/0005-2787(71)90608-3.