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双硫仑对二甲基肼诱导的大肠肿瘤形成的抑制作用。

Inhibition of dimethylhydrazine-induced neoplasia of the large intestine by disulfiram.

作者信息

Wattenberg L W

出版信息

J Natl Cancer Inst. 1975 Apr;54(4):1005-6. doi: 10.1093/jnci/54.4.1005.

DOI:10.1093/jnci/54.4.1005
PMID:1127713
Abstract

Disulfiram added to the diet of female CF1 mice inhibited large-bowel neoplasia produced by repeated subcutaneous administrations of dimethylhydrazine (DMH). The mice on a control diet all showed multiple tumors of the large bowel after DMH treatments, whereas there was no evidence of neoplasia in mice given disulfiram.

摘要

在雌性CF1小鼠的饮食中添加双硫仑可抑制因反复皮下注射二甲基肼（DMH）而产生的大肠肿瘤形成。食用对照饮食的小鼠在接受DMH治疗后均出现多个大肠肿瘤，而给予双硫仑的小鼠则没有肿瘤形成的迹象。

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