Vogt W, Hinsch B, Schmidt G, Von Zabern I
Immunology. 1979 Jan;36(1):131-7.
Propamidine, one of the diamidines used against infections with babesiae has inhibitory and enhancing effects on complement activation as assessed by immune haemolysis of sensitized sheep red cells. Utilization of C1 is powerfully, that of C3 weakly improved by propamidine while activation and/or fixation of C4, C5 and to a lesser degree of C8 and C9 are inhibited. At low concentrations of propamidine (less than 2 mM) the enhancing effects, at higher concentrations the inhibitory effects predominate. Inhibition is produced, in some cases certainly, in others likely, by interference of propamidine with binding properties of complement components. None of the complement enzymes, C1s, C42 or C3bBb was inhibited in its hydrolytic activity. The possible significance of propamidine actions is discussed.
丙烷脒是一种用于对抗巴贝斯虫感染的双脒类药物，通过致敏绵羊红细胞的免疫溶血试验评估，它对补体激活具有抑制和增强作用。丙烷脒能强力促进C1的利用，对C3的利用促进作用较弱，同时抑制C4、C5以及程度较轻的C8和C9的激活和/或固定。在低浓度丙烷脒（小于2 mM）时，增强作用占主导，在高浓度时，抑制作用占主导。在某些情况下，丙烷脒肯定会通过干扰补体成分的结合特性产生抑制作用，在其他情况下则可能如此。补体酶C1s、C42或C3bBb的水解活性均未受到抑制。文中讨论了丙烷脒作用的可能意义。
