Palmer D L, Zaman S N
Infect Immun. 1979 Jan;23(1):27-30. doi: 10.1128/iai.23.1.27-30.1979.
Cholera toxin may depress cell-mediated immunity by stimulation of adenyl cyclase and production of cyclic AMP in cellular systems or when given parenterally to experimental animals. Whether or not similar effects might be found during clinical infection with Vibrio cholerae was the subject of this study. Delayed hypersensitivity reactions to skin test antigens were found to be markedly depressed in Bengali patients with cholera 24 h after fluid repletion. Skin test response rates were lower in children and in adults with the disease than in both normal adults and children or in adults with an equivalent degree of malnutrition. Patients with equal degrees of dehydration due to noncholera diarrhea were significantly less immunosuppressed. Concurrent depression of other manifestations of cell-mediated immunity was not found.
霍乱毒素可通过刺激细胞系统中的腺苷酸环化酶并产生环磷酸腺苷，或在对实验动物进行肠胃外给药时，抑制细胞介导的免疫。在霍乱弧菌临床感染期间是否会发现类似作用是本研究的主题。研究发现，在孟加拉霍乱患者补液24小时后，对皮肤试验抗原的迟发型超敏反应明显受到抑制。患有该疾病的儿童和成人的皮肤试验反应率低于正常成人和儿童，也低于同等程度营养不良的成人。因非霍乱性腹泻导致同等程度脱水的患者免疫抑制明显较轻。未发现细胞介导免疫的其他表现同时受到抑制。
