Cushing A H, Murphy S, Skipper B E
Inflammation. 1981 Mar;5(1):55-60. doi: 10.1007/BF00910779.
Migration of rabbit peritoneal macrophages toward casein-serum was inhibited by preincubation of the cells with heat-labile toxin of Escherichia coli in direct relationship to the concentration of toxin in the incubation mixture. Cells preincubated with heated toxin or with toxin-antiserum migrated the same as those which had been incubated in toxin-free media. Toxin-preincubated cells had levels of cyclic AMP which were increased in direct relationship to the concentration of toxin in the preincubation mixture. Heated toxin failed to induce increased levels of cAMP in the cells at the highest concentration tested.
兔腹膜巨噬细胞向酪蛋白 - 血清的迁移受到抑制，这种抑制作用与细胞在大肠杆菌不耐热毒素中预孵育有关，且与孵育混合物中毒素的浓度呈直接关系。用加热后的毒素或毒素 - 抗血清预孵育的细胞，其迁移情况与在无毒素培养基中孵育的细胞相同。经毒素预孵育的细胞中，环磷酸腺苷（cAMP）水平升高，且与预孵育混合物中毒素的浓度呈直接关系。在测试的最高浓度下，加热后的毒素未能诱导细胞中cAMP水平升高。
