Palmer D L, Koster F T, Alam A K, Islam M R
J Infect Dis. 1976 Jul;134(1):8-14. doi: 10.1093/infdis/134.1.8.
The severity of diarrhea and nutritional status were measured in a prospective study of 97 patients hospitalized with cholera in Dacca, Bangladesh. Ninety-five percent of both adults and children were below their respective medians in weight as related to height; greater than 15% of each group showed second-degree protein-calorie malnutrition. Duration of diarrhea, but no volume of stool per hour, was prolonged by 30%-70% in those adults and children suffering from more severe malnutrition. The increased stool loss was unrelated to antibiotic usage, to presence of intestinal parasites, or to the refeeding diet given. It is suggested that the prolongation of diarrhea represents the continued effect of cholera toxin that is irreversibly bound to intestinal mucosal cells, the replacement of which would be retarded under conditions of poor nutrition.
在孟加拉国达卡对97名因霍乱住院的患者进行的一项前瞻性研究中，对腹泻的严重程度和营养状况进行了测量。与身高相关的体重方面，95%的成人和儿童均低于各自的中位数；每组超过15%的人表现出二度蛋白质 - 热量营养不良。在患有更严重营养不良的成人和儿童中，腹泻持续时间延长了30% - 70%，但每小时的粪便量未延长。粪便损失增加与抗生素使用、肠道寄生虫的存在或给予的再喂养饮食无关。有人提出，腹泻时间延长代表霍乱毒素持续作用，该毒素不可逆地结合到肠黏膜细胞上，在营养状况不佳的情况下，肠黏膜细胞的替换会受到阻碍。
