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N-Hydroxylation of 2-aminofluorene in the guinea pig and by guinea pig liver microsomes in vitro.

作者信息

Kiese M, Renner G, Wiedemann I

出版信息

Naunyn Schmiedebergs Arch Exp Pathol Pharmakol. 1966;252(5):418-23. doi: 10.1007/BF00258640.

DOI:10.1007/BF00258640
PMID:4222798
Abstract
摘要

相似文献

1
N-Hydroxylation of 2-aminofluorene in the guinea pig and by guinea pig liver microsomes in vitro.豚鼠体内及豚鼠肝微粒体体外对2-氨基芴的N-羟基化作用。
Naunyn Schmiedebergs Arch Exp Pathol Pharmakol. 1966;252(5):418-23. doi: 10.1007/BF00258640.
2
Metabolism of N-hydroxy-2-acetylaminofluorene and N-hydroxy-2-aminofluorene by guinea pig liver microsomes.豚鼠肝微粒体对N-羟基-2-乙酰氨基芴和N-羟基-2-氨基芴的代谢
Cancer Res. 1982 Nov;42(11):4712-8.
3
Biochemical basis for the resistance of guinea-pig and monkey to the carcinogenic effects of arylamines and arylamides.
Xenobiotica. 1980 Jul-Aug;10(7-8):565-71. doi: 10.3109/00498258009033791.
4
Electrophilic N-acetoxyaminoarenes derived from carcinogenic N-hydroxy-N-acetylaminoarenes by enzymatic deacetylation and transacetylation in liver.亲电N-乙酰氧基氨基芳烃是由致癌性N-羟基-N-乙酰氨基芳烃在肝脏中通过酶促脱乙酰化和转乙酰化作用衍生而来的。
Biochim Biophys Acta. 1972 Dec 29;286(2):272-98. doi: 10.1016/0304-4165(72)90265-6.
5
Preventive effect of isoflurane on destruction of cytochrome P450 during reductive dehalogenation of carbon tetrachloride in guinea-pig liver microsomes.异氟烷对豚鼠肝微粒体中四氯化碳还原脱卤过程中细胞色素P450破坏的预防作用。
Drug Metabol Drug Interact. 1997;14(2):99-107. doi: 10.1515/dmdi.1997.14.2.99.
6
[N-hydroxylation of sulfanilamide to p-hydroxylaminobenzolsulfonamide by liver microsomes].[肝脏微粒体将磺胺嘧啶羟基化为对羟基氨基苯磺酰胺]
Naunyn Schmiedebergs Arch Exp Pathol Pharmakol. 1965 Nov 4;252(1):32-42.
7
Main pathway for mutagenic activation of 2-acetylaminofluorene by guinea pig liver homogenates.豚鼠肝脏匀浆对2-乙酰氨基芴进行诱变激活的主要途径。
Biochem Biophys Res Commun. 1979 Oct 12;90(3):750-6. doi: 10.1016/0006-291x(79)91891-6.
8
Metabolic N-oxidation of atropine, hyoscine and the corresponding nor-alkaloids by guinea-pig liver microsomal preparations.豚鼠肝微粒体制剂对阿托品、东莨菪碱及相应去甲生物碱的代谢性N-氧化作用。
J Pharm Pharmacol. 1976 Sep;28(9):687-91. doi: 10.1111/j.2042-7158.1976.tb02837.x.
9
Microsomal metabolism of arylamides by the rat and guinea pig--I. Oxidation of N-3-fluorenylacetamide at carbon-atom-9--a major metabolic reaction.大鼠和豚鼠对芳酰胺的微粒体代谢——I. N-3-芴基乙酰胺在9位碳原子处的氧化——一种主要的代谢反应。
Biochem Pharmacol. 1978;27(11):1581-9. doi: 10.1016/0006-2952(78)90489-6.
10
Effects on hepatic microsomal N- and C-oxygenation of aromatic amines by in vivo corticosteroid or aminofluorene treatment, diet, or stress.
Cancer Res. 1968 Feb;28(2):264-73.

引用本文的文献

1
N-Acetyl-2-Aminofluorene (AAF) Processing in Adult Rat Hepatocytes in Primary Culture Occurs by High-Affinity Low-Velocity and Low-Affinity High-Velocity AAF Metabolite-Forming Systems.N-乙酰-2-氨基芴（AAF）在原代培养的成年大鼠肝细胞中的代谢途径为高亲和力低速度和低亲和力高速度 AAF 代谢产物形成系统。
Toxicol Sci. 2018 May 1;163(1):26-34. doi: 10.1093/toxsci/kfy006.
2
Synthesis of 2-nitrosofluorene by peracetic acid oxidation of 2-aminofluorene.通过过氧乙酸氧化2-氨基芴合成2-亚硝基芴。
Experientia. 1968 Feb 15;24(2):108. doi: 10.1007/BF02146922.

本文引用的文献

1
THE COMPARATIVE CARCINOGENICITIES OF 2-ACETYLAMINOFLUORENE AND ITS N-HYDROXY METABOLITE IN MICE, HAMSTERS, AND GUINEA PIGS.2-乙酰氨基芴及其N-羟基代谢物在小鼠、仓鼠和豚鼠中的致癌性比较
Cancer Res. 1964 Dec;24:2018-31.
2
METABOLISM OF N-2-FLUORENYLACETAMIDE IN THE HAMSTER.
Toxicol Appl Pharmacol. 1964 Jul;6:427-33. doi: 10.1016/s0041-008x(64)80008-9.
3
ENZYMATIC N-HYDROXYLATION OF THE CARCINOGEN 2-ACETYLAMINOFLUORENE AND THE METABOLISM OF N-HYDROXY-2-ACETYLAMINOFLUORENE-9-14C IN VITRO.致癌物2-乙酰氨基芴的酶促N-羟基化及N-羟基-2-乙酰氨基芴-9-¹⁴C的体外代谢
J Biol Chem. 1964 May;239:1589-96.
4
THE METABOLISM OF N-2-FLUORENYLACETAMIDE IN THE CAT: EVIDENCE FOR GLUCURONIC ACID CONJUGATES.
Biochem Pharmacol. 1964 Mar;13:469-75. doi: 10.1016/0006-2952(64)90167-4.
5
ACTIVATION AND DETOXIFICATION OF N-2-FLUORENYLACETAMIDE IN MAN.N-2-芴基乙酰胺在人体中的活化与解毒作用。
Cancer Res. 1964 Apr;24:475-9.
6
N-hydroxylation of the carcinogen 2-acetylaminofluorene by rabbit-liver microsomes.兔肝微粒体对致癌物2-乙酰氨基芴的N-羟基化作用。
Biochim Biophys Acta. 1962 Dec 17;65:564-6. doi: 10.1016/0006-3002(62)90477-8.
7
The N- and ring-hydroxylation of 2-acetylaminofluorene and the failure to detect N-acetylation of 2-aminofluorene in the dog.2-乙酰氨基芴的N-和环羟基化以及在犬体内未检测到2-氨基芴的N-乙酰化。
Cancer Res. 1963 Jun;23:790-800.
8
The N- and ringhydroxylation of 2-acetylaminofluorene during carcinogenesis in the rat.大鼠致癌过程中2-乙酰氨基芴的N-羟基化和环羟基化。
Cancer Res. 1960 Jul;20:950-62.
9
N-Hydroxylation: A new metabolic reaction observed in the rat with the carcinogen 2-acetylaminofluorene.N-羟基化：在大鼠体内观察到的与致癌物2-乙酰氨基芴相关的一种新的代谢反应。
J Biol Chem. 1960 Mar;235:885-8.
10
Chemistry, carcinogenicity, and metabolism of 2-fluorenamine and related compounds.2-芴胺及相关化合物的化学性质、致癌性和代谢
Adv Cancer Res. 1958;5:331-431. doi: 10.1016/s0065-230x(08)60415-7.