Massof R W, Finkelstein D
Invest Ophthalmol Vis Sci. 1979 Mar;18(3):263-72.
The present study evaluates rod sensitivity relative to cone sensitivity in retinitis pigmentosa patients. From perimetric measures of absolute thresholds to long- and short-wavelength stimuli, we find the results can be characterized in three different ways. For one group of patients it appears that only cone function is present in all parts of the visual field. For another group of patients, despite large losses in absolute sensitivity, rod sensitivity still exceeds cone sensitivity by at least the normal factor, suggesting concomitant rod and cone sensitivity losses. For a third group of patients it appears that central retinal thresholds are determined primarily by cones, midperipheral retinal thresholds determined by a composite of rod and cone function, and far- peripheral thresholds determined predominately by rods. The argument is put forward that the different groups of threshold results represent different disease mechanisms rather than different stages in the progression of a single disease process.
本研究评估了视网膜色素变性患者视杆细胞敏感性相对于视锥细胞敏感性的情况。通过对长波长和短波长刺激的绝对阈值进行视野测量，我们发现结果可以用三种不同方式来描述。对于一组患者，似乎视野的所有部分仅存在视锥细胞功能。对于另一组患者，尽管绝对敏感性大幅下降，但视杆细胞敏感性仍至少以正常倍数超过视锥细胞敏感性，这表明视杆细胞和视锥细胞敏感性同时丧失。对于第三组患者，似乎中央视网膜阈值主要由视锥细胞决定，中周边视网膜阈值由视杆细胞和视锥细胞功能的组合决定，而远周边阈值主要由视杆细胞决定。有人提出，不同组的阈值结果代表不同的疾病机制，而非单一疾病进程进展中的不同阶段。
