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视网膜色素变性中视网膜电图阈值与全视野视杆细胞视网膜电图之间的关系。

The relationship between rod perimetric thresholds and full-field rod ERGs in retinitis pigmentosa.

作者信息

Birch D G, Herman W K, deFaller J M, Disbrow D T, Birch E E

出版信息

Invest Ophthalmol Vis Sci. 1987 Jun;28(6):954-65.

PMID:3583634
Abstract

Dark-adapted static perimetric fields and rod full-field electroretinograms (ERGs) were measured in normal subjects and 15 patients with retinitis pigmentosa. Psychophysical thresholds for short-wavelength stimuli were obtained from 76 locations across the retina on a modified Octopus 201 perimeter; threshold differences to short- and long-wavelength stimuli were used to determine whether rods were mediating threshold at each retinal location. Full-field rod ERG peak-to-peak amplitude as a function of retinal illuminance was analyzed by determining the parameters of the best-fit Naka-Rushton equation. Rod ERG thresholds and mean rod perimetric thresholds were significantly correlated with a slope of approximately 1.0. Log k was positively correlated with threshold elevation in the region of peak field sensitivity and log Vmax was positively correlated with log rod visual field area. These results demonstrate correspondence between parameters derived from rod visual fields and parameters derived from the Naka-Rushton analysis of the full-field rod ERG.

摘要

在正常受试者和15名视网膜色素变性患者中测量了暗适应静态视野和视网膜杆体全视野视网膜电图(ERG)。在改良的Octopus 201视野计上,从视网膜上的76个位置获得短波长刺激的心理物理学阈值;使用短波长和长波长刺激的阈值差异来确定在每个视网膜位置杆体是否介导阈值。通过确定最佳拟合中谷-拉什顿方程的参数,分析全视野视网膜杆体ERG峰峰值幅度作为视网膜照度的函数。视网膜杆体ERG阈值和平均视网膜杆体视野阈值显著相关,斜率约为1.0。对数k与峰值视野敏感度区域的阈值升高呈正相关,对数Vmax与对数视网膜杆体视野面积呈正相关。这些结果表明,从视网膜杆体视野得出的参数与从全视野视网膜杆体ERG的中谷-拉什顿分析得出的参数之间存在对应关系。

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