Durodola J I
J Natl Med Assoc. 1979 Feb;71(2):165-6.
Burkitt lymphoma was diagnosed in a patient during the third trimester of pregnancy. Treatment with a low-dose, seven-day course of intravenous cyclophosphamide gave a good response which permitted the pregnancy to be carried to term, with delivery of a normal infant. When the mother received cyclophosphamide during lactation while the baby was breast-fed, the infant's leukocyte and platelet counts were rapidly depressed. Results in this patient and a survey of reported cases in which cyclophosphamide was administered during pregnancy and lactation lead to the conclusions that (1) low-dose intravenous cyclophosphamide therapy is not hazardous to the fetus during late pregnancy; (2) mammary concentration of the drug is too toxic to the infant's bone marrow; and (3) breast-feeding the baby should be suspended during the period the mother is receiving cyclophosphamide treatment.
一名患者在妊娠晚期被诊断为伯基特淋巴瘤。采用低剂量静脉注射环磷酰胺进行为期七天的治疗，效果良好，使妊娠得以足月分娩，产下一名正常婴儿。母亲在哺乳期接受环磷酰胺治疗且婴儿进行母乳喂养时，婴儿的白细胞和血小板计数迅速下降。该患者的情况以及对妊娠和哺乳期使用环磷酰胺的报道病例调查得出以下结论：（1）妊娠晚期低剂量静脉注射环磷酰胺治疗对胎儿无危害；（2）药物在乳腺中的浓度对婴儿骨髓毒性过大；（3）母亲接受环磷酰胺治疗期间应暂停母乳喂养婴儿。
