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1
Effect of pH on the inhibition of the nicotinamide-adenine dinucleotide-specific isocitrate dehydrogenase from baker's yeast by anions.pH对阴离子抑制面包酵母烟酰胺腺嘌呤二核苷酸特异性异柠檬酸脱氢酶的影响。
Biochem J. 1968 Sep;109(3):361-8. doi: 10.1042/bj1090361.
2
Kinetic behaviour of NAD plus-specific isocitrate dehydrogenase from baker's yeast and inhibition by AMP.
Ital J Biochem. 1970 Mar-Apr;19(2):100-10.
3
Polymeric forms of yeast nicotinamide-adenine dinucleotide-specific isocitrate dehydrogenase in the presence of various ligands.在各种配体存在的情况下酵母烟酰胺腺嘌呤二核苷酸特异性异柠檬酸脱氢酶的聚合形式
Ital J Biochem. 1977 Nov-Dec;26(6):473-86.
4
Anion and substrate inhibition and kinetic behavior of NAD+-specific isocitrate dehydrogenase from baker's yeast.面包酵母中NAD⁺特异性异柠檬酸脱氢酶的阴离子和底物抑制作用及动力学行为
Biochim Biophys Acta. 1967 Mar 15;132(2):232-43. doi: 10.1016/0005-2744(67)90142-8.
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The effects of pH and citrate on the activity of nicotinamideA-denine dinucleotide-specific isocitrate dehydrogenase from pea mitochondria.pH值和柠檬酸盐对豌豆线粒体中烟酰胺腺嘌呤二核苷酸特异性异柠檬酸脱氢酶活性的影响。
Biochem J. 1969 Aug;113(5):813-20. doi: 10.1042/bj1130813.
6
Affinity chromatography of yeast nicotinamide-adenine dinucleotide-specific isocitrate dehydrogenase on immobilized nicotinamide-adenine dinucleotide. Effects of ligands.酵母烟酰胺腺嘌呤二核苷酸特异性异柠檬酸脱氢酶在固定化烟酰胺腺嘌呤二核苷酸上的亲和层析。配体的影响。
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Nicotinamide-adenine dinucleotide-specific isocitrate dehydrogenase from pea mitochondria. Purification and properties.豌豆线粒体中烟酰胺腺嘌呤二核苷酸特异性异柠檬酸脱氢酶。纯化及特性
Biochem J. 1967 Nov;105(2):729-34. doi: 10.1042/bj1050729.
8
Kinetic regulation of yeast NAD-specific isocitrate dehydrogenase by citrate.柠檬酸对酵母NAD特异性异柠檬酸脱氢酶的动力学调节
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Biochemical studies in marine species--I. NADP(+)-dependent isocitrate dehydrogenase from turbot liver (Scophthalmus maximus L.).海洋物种的生化研究——I. 大菱鲆肝脏（Scophthalmus maximus L.）中依赖NADP(+)的异柠檬酸脱氢酶
Comp Biochem Physiol B. 1989;93(4):823-8. doi: 10.1016/0305-0491(89)90053-9.

引用本文的文献

1
Purification of yeast isocitrate dehydrogenase.酵母异柠檬酸脱氢酶的纯化
Biochem J. 1972 Oct;129(5):1119-24. doi: 10.1042/bj1291119.

本文引用的文献

1
Di- and triphosphopyridine nucleotide isocitric dehydrogenases in yeast.酵母中的二磷酸和三磷酸吡啶核苷酸异柠檬酸脱氢酶
J Biol Chem. 1951 Mar;189(1):123-36.
2
A KINETIC MODEL FOR THE MECHANISM OF ALLOSTERIC ACTIVATION OF NICOTINAMIDE-ADENINE DINUCLEOTIDE-SPECIFIC ISOCRITIC DEHYDROGENASE.烟酰胺腺嘌呤二核苷酸特异性异柠檬酸脱氢酶变构激活机制的动力学模型
Biochemistry. 1965 Mar;4:410-21. doi: 10.1021/bi00879a006.
3
KINETICS OF REGULATORY ENZYMES. KINETIC ORDER OF THE YEAST DIPHOSPHOPYRIDINE NUCLEOTIDE ISOCITRATE DEHYDROGENASE REACTION AND A MODEL FOR THE REACTION.调节酶的动力学。酵母二磷酸吡啶核苷酸异柠檬酸脱氢酶反应的动力学级数及反应模型。
J Biol Chem. 1965 Jun;240:2682-90.
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DPN-SPECIFIC ISOCITRATE-DEHYDROGENASE OF MITOCHONDRIA. II. PH-DEPENDENCE OF THE KINETICS AND THE MECHANISM OF ACTIVATION.线粒体中糖尿病周围神经病变特异性异柠檬酸脱氢酶。II. 动力学的pH依赖性及激活机制
Biochem Z. 1965 Feb 8;341:199-223.
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NICOTINAMIDE ADENINE DINUCLEOTIDE-SPECIFIC ISOCITRIC DEHYDROGENASE. A POSSIBLE REGULATORY PROTEIN.烟酰胺腺嘌呤二核苷酸特异性异柠檬酸脱氢酶。一种可能的调节蛋白。
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THE STABILITY CONSTANTS OF METAL-ADENINE NUCLEOTIDE COMPLEXES.金属 - 腺嘌呤核苷酸络合物的稳定常数
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CONTROL OF DPN-SPECIFIC ISOCITRIC DEHYDROGENASE ACTIVITY BY PRECURSOR ACTIVATION AND END PRODUCT INHIBITION.通过前体激活和终产物抑制对糖尿病周围神经病变特异性异柠檬酸脱氢酶活性的调控
Biochem Biophys Res Commun. 1963 Aug 20;12:510-5. doi: 10.1016/0006-291x(63)90325-5.
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THE EFFECT OF ADENYLIC ACID ON YEAST NICOTINAMIDE ADENINE DINUCLEOTIDE ISOCITRATE DEHYDROGENASE, A POSSIBLE METABOLIC CONTROL MECHANISM.腺苷酸对酵母烟酰胺腺嘌呤二核苷酸异柠檬酸脱氢酶的影响，一种可能的代谢控制机制。
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pH对阴离子抑制面包酵母烟酰胺腺嘌呤二核苷酸特异性异柠檬酸脱氢酶的影响。

Effect of pH on the inhibition of the nicotinamide-adenine dinucleotide-specific isocitrate dehydrogenase from baker's yeast by anions.

作者信息

Cennamo C, Montecuccoli G, Bonaretti G, Razzoli L

出版信息

Biochem J. 1968 Sep;109(3):361-8. doi: 10.1042/bj1090361.

DOI:10.1042/bj1090361
PMID:4234830
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1186830/
Abstract
  1. The sensitivity of the NAD(+)-specific isocitrate dehydrogenase from baker's yeast towards inhibition by anions decreases with decrease in pH. The patterns of the pH-dependence of the enzymic activity can be explained by this effect. 2. In the presence of a high isocitrate concentration, citrate, unlike AMP, has no antagonizing effect on the inhibition of the enzyme by anions. In the presence of AMP, citrate inhibits the enzyme at high isocitrate concentration and activates at low isocitrate concentration. 3. The effects on the enzymic activity of the previous incubation of the enzyme were studied in relation to the substrate concentration, the chloride concentration and the presence of citrate and AMP.
摘要
  1. 面包酵母中NAD(+)特异性异柠檬酸脱氢酶对阴离子抑制的敏感性随pH降低而降低。酶活性的pH依赖性模式可由此效应解释。2. 在高异柠檬酸浓度存在下，与AMP不同，柠檬酸对阴离子对该酶的抑制没有拮抗作用。在AMP存在下，柠檬酸在高异柠檬酸浓度时抑制该酶，在低异柠檬酸浓度时激活该酶。3. 研究了酶预先孵育对酶活性的影响，涉及底物浓度、氯离子浓度以及柠檬酸和AMP的存在情况。