继发性淀粉样变性中酸性粘多糖物质的组织化学研究
Histochemical investigation of acid mucosubstances in secondary amyloidosis.
作者信息
Pennock C A, Burns J, Massarella G
出版信息
J Clin Pathol. 1968 Sep;21(5):578-81. doi: 10.1136/jcp.21.5.578.
Abstract
Sections of liver and spleen from six cases of secondary amyloidosis have been examined, by various improved histochemical methods, for acidic mucosubstances. The results indicate a complex in amyloid deposits of protein and sulphated mucopolysaccharides in which the principal substance is heparan sulphate with traces of chondroitin sulphates. Deposits also contain sialic acid. The results are compared with chemical analyses of the same tissues and isolated fibrils which confirm the presence of heparan sulphate, chondroitin sulphates, and a sialic acid containing protein.
摘要
运用多种改良的组织化学方法，对6例继发性淀粉样变性患者的肝脏和脾脏切片进行了酸性黏液物质检测。结果表明，淀粉样沉积物中存在蛋白质与硫酸化黏多糖的复合物，其中主要物质是硫酸乙酰肝素，并含有微量硫酸软骨素。沉积物中还含有唾液酸。将这些结果与对相同组织及分离出的原纤维进行的化学分析结果进行比较，证实了硫酸乙酰肝素、硫酸软骨素以及一种含唾液酸蛋白质的存在。
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