Hairston N G, de Meillon B
Bull World Health Organ. 1968;38(6):935-41.
The high biting rate of Culex pipiens fatigans in Rangoon, combined with a low prevalence of microfilaraemia due to Wuchereria bancrofti, suggested a poor efficiency of transmission. Data obtained by the WHO Filariasis Research Unit in Rangoon were analysed, and the efficiency of the parasite from Stage III larva in the mosquito to the production of microfilariae was estimated as 6.04-6.71 x 10(-5), indicating that an average of around 15 500 bites by "infective" mosquitos is necessary to produce 1 case of microfilaraemia. This surprising result prompted a step-by-step analysis of the success of the parasite through departure from the mosquito, penetration of host tissues, survival to maturity, and encountering a mate in the human host. It was hoped that the second approach would identify some discrepancy in the original analysis, but when all sources of loss were combined, it was estimated that the expected efficiency was 4.78 x 10(-5). The two estimates are within observational error of each other. The degree to which the two approaches agree leads to the conclusion that survival of the parasite is reasonably well known at all stages, and the calculations indicate that a high proportion of the population of Rangoon must be carrying parasites that are either dead or immature. A complete quantitative statement of the epidemiology of W. bancrofti seems to be attainable.
在仰光，致倦库蚊的高叮咬率，再加上班氏吴策线虫所致微丝蚴血症的低流行率，表明传播效率很低。对世界卫生组织仰光丝虫病研究单位获得的数据进行了分析，从蚊子体内的Ⅲ期幼虫到产生微丝蚴的寄生虫效率估计为6.04 - 6.71×10⁻⁵，这表明平均约需15500次“感染性”蚊子叮咬才能产生1例微丝蚴血症。这一惊人结果促使对寄生虫从蚊子传播开始、穿透宿主组织、存活至成熟以及在人类宿主中遇到配偶等各个环节的成功情况进行逐步分析。原本希望第二种方法能找出原始分析中的一些差异，但当将所有损失来源综合起来时，估计预期效率为4.78×10⁻⁵。这两个估计值在彼此的观测误差范围内。两种方法的一致程度得出结论，即寄生虫在各个阶段的存活情况已相当清楚，并且计算表明仰光很大一部分人口必定携带已死亡或未成熟的寄生虫。班氏吴策线虫流行病学的完整定量描述似乎是可以实现的。
