大鼠干扰素的生产、纯化及特性分析
Production, purification and characterization of rat interferon.
作者信息
Lin L S, Abreu S L
出版信息
Arch Virol. 1979;62(3):221-7. doi: 10.1007/BF01317554.
PMID:42377
Abstract
Priming with heterologous mouse interferon, increased production of an antiviral substance induced in rat diploid fibroblasts by Newcastle disease virus. This substance was characterized as an acid stable interferon. This rat interferon exhibited marked cross-species antiviral activity when tested in mouse L929B cells, guinea pig embryo fibroblasts, human fibroblasts and bovine cells but was not active on chick embryo cells.
摘要
用异源小鼠干扰素进行预处理，可增加新城疫病毒在大鼠二倍体成纤维细胞中诱导产生的一种抗病毒物质的产量。这种物质被鉴定为一种酸稳定型干扰素。当在小鼠L929B细胞、豚鼠胚胎成纤维细胞、人成纤维细胞和牛细胞中进行测试时，这种大鼠干扰素表现出显著的跨物种抗病毒活性，但对鸡胚细胞无活性。
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