干扰素信使核糖核酸：在异源细胞中的翻译
Interferon messenger RNA: translation in heterologous cells.
作者信息
de Maeyer-Guignard J, de Maeyer E, Montagnier L
出版信息
Proc Natl Acad Sci U S A. 1972 May;69(5):1203-7. doi: 10.1073/pnas.69.5.1203.
Abstract
A viral inhibitor with the characteristics of mouse interferon is produced by avian and simian cells preincubated with RNA extracted from interferon-producing mouse cells. Similarly, RNA extracted from interferon-producing monkey cells induces a monkey interferon-like substance in avian cells and also in a line of simian cells, VERO, which normally lacks the capacity to produce its own interferon. In both cases, the RNA effect is inhibited by treatment of the receptor cells by cycloheximide, but not by actinomycin D. We conclude that interferon messenger RNA has been translated in the receptor cells. Thus, the production of interferon in heterologous cells can be used as a sensitive assay of interferon messenger RNA.
摘要
具有小鼠干扰素特性的病毒抑制剂是由用从产生干扰素的小鼠细胞中提取的RNA预孵育的禽细胞和猴细胞产生的。同样，从产生干扰素的猴细胞中提取的RNA在禽细胞以及在通常缺乏产生自身干扰素能力的猴细胞系VERO中诱导出一种类似猴干扰素的物质。在这两种情况下，用环己酰亚胺处理受体细胞可抑制RNA的作用，但放线菌素D则无此作用。我们得出结论，干扰素信使RNA已在受体细胞中被翻译。因此，在异源细胞中产生干扰素可作为干扰素信使RNA的一种灵敏检测方法。
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Reversible inhibition of interferon synthesis by puromycin: evidence for an interferon-specific messenger RNA.嘌呤霉素对干扰素合成的可逆抑制：干扰素特异性信使核糖核酸的证据
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