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产生溶血素的细胞克隆的成熟。I. 体外对红细胞抗原的溶血素反应诱导期的动力学。

Maturation of hemolysin-producing cell clones. I. The kinetics of the induction period of an in vitro hemolysin response to erythrocyte antigen.

作者信息

Saunders G C

出版信息

J Exp Med. 1969 Sep 1;130(3):543-56. doi: 10.1084/jem.130.3.543.

DOI:10.1084/jem.130.3.543
PMID:4241197
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2138706/
Abstract

INVESTIGATIONS OF THE INDUCTION PERIOD OF AN IN VITRO HEMOLYSIN RESPONSE TO SHEEP ERYTHROCYTE ANTIGEN REVEALED THE FOLLOWING

  1. After antigen stimulation precursors of plaque-forming cells rapidly maturate to the point of hemolysin production. 2. Initial maturation probably occurs in the absence of cell division. 3. After initial maturation, a latent period of about 12 hr occurs before the first doubling of PFC. 4. At least the first three cell doublings are synchronous, with a generation time of 7-8 hr. 5. Synchronous cell division implies that all precursor cells are at the same point in the cell cyde when they are initially stimulated.
摘要

对体外针对绵羊红细胞抗原的溶血素反应诱导期的研究揭示了以下几点

  1. 抗原刺激后,形成噬斑细胞的前体细胞迅速成熟至产生溶血素的阶段。2. 初始成熟可能在无细胞分裂的情况下发生。3. 初始成熟后,在形成噬斑细胞首次倍增前会出现约12小时的潜伏期。4. 至少前三次细胞倍增是同步的,代时为7 - 8小时。5. 同步细胞分裂意味着所有前体细胞在最初受到刺激时处于细胞周期的同一阶段。

相似文献

1
Maturation of hemolysin-producing cell clones. I. The kinetics of the induction period of an in vitro hemolysin response to erythrocyte antigen.产生溶血素的细胞克隆的成熟。I. 体外对红细胞抗原的溶血素反应诱导期的动力学。
J Exp Med. 1969 Sep 1;130(3):543-56. doi: 10.1084/jem.130.3.543.
2
Maturation of hemolysin-producing cell clones. II. The appearance and localization of precursor units in lymphoid tissues of neonatal mice.产溶血素细胞克隆的成熟。II. 新生小鼠淋巴组织中前体单位的出现及定位。
J Exp Med. 1970 Jun 1;131(6):1261-70. doi: 10.1084/jem.131.6.1261.
3
Restriction of the capacity to respond to two antigens by single precursors of antibody-producing cells in culture.培养中产生抗体细胞的单个前体细胞对两种抗原应答能力的限制。
J Exp Med. 1969 Jan 1;129(1):141-52. doi: 10.1084/jem.129.1.141.
4
Immune responses in vitro. 3. Development of primary gamma-M, gamma-G, and gamma-A plaque-forming cell responses in mouse spleen cell cultures stimulated with heterologous erythrocytes.体外免疫反应。3. 用异种红细胞刺激小鼠脾细胞培养物中主要γ-M、γ-G和γ-A斑块形成细胞反应的发展。
J Exp Med. 1971 Aug 1;134(2):395-416. doi: 10.1084/jem.134.2.395.
5
Antigenic competition between heterologous erythrocytes in mice: interference with competition-inducing effect of sheep erythrocytes by inclusion of non-competing antigen.小鼠体内异源红细胞之间的抗原竞争:通过加入非竞争性抗原对绵羊红细胞竞争诱导效应的干扰
J Immunol. 1975 Jul;115(1):85-90.
6
Cell to cell interaction in the immune response. II. The source of hemolysin-forming cells in irradiated mice given bone marrow and thymus or thoracic duct lymphocytes.免疫反应中的细胞间相互作用。II. 给受照射小鼠输注骨髓、胸腺或胸导管淋巴细胞后溶血素形成细胞的来源。
J Exp Med. 1968 Oct 1;128(4):821-37. doi: 10.1084/jem.128.4.821.
7
The rate of division of antibody-forming cells during the early primary immune response.初次免疫应答早期抗体形成细胞的分裂速率。
J Exp Med. 1968 May 1;127(5):983-1002. doi: 10.1084/jem.127.5.983.
8
The life cycle of antibody-forming cells. I. The generation time of 19S hemolytic plaque-forming cells during the primary and secondary responses.抗体形成细胞的生命周期。I. 初次和二次应答期间19S溶血空斑形成细胞的生成时间。
J Exp Med. 1968 Nov 1;128(5):895-925. doi: 10.1084/jem.128.5.895.
9
The induction of haemolysin producing cells in vitro: inhibition by antiglobulin antisera.体外溶血素产生细胞的诱导:抗球蛋白抗血清的抑制作用
Immunology. 1971 Jan;20(1):29-36.
10
Virus-replicating T cells in the immune response of mice. I. Virus plaque assay of the lymphocytes reactive to sheep erythrocytes.小鼠免疫反应中病毒复制T细胞。I. 对绵羊红细胞反应性淋巴细胞的病毒空斑试验
J Exp Med. 1977 Feb 1;145(2):390-404. doi: 10.1084/jem.145.2.390.

引用本文的文献

1
Electrophoretically homogeneous antibody synthesized by spleen foci of irradiated repopulated mice.由经辐照再增殖小鼠脾脏灶合成的电泳纯抗体。
J Exp Med. 1970 Aug 1;132(2):199-210. doi: 10.1084/jem.132.2.199.
2
Maturation of hemolysin-producing cell clones. II. The appearance and localization of precursor units in lymphoid tissues of neonatal mice.产溶血素细胞克隆的成熟。II. 新生小鼠淋巴组织中前体单位的出现及定位。
J Exp Med. 1970 Jun 1;131(6):1261-70. doi: 10.1084/jem.131.6.1261.
3
Repetitive maturation cycles in a cultured mouse myeloma.培养的小鼠骨髓瘤中的重复成熟周期
J Cell Biol. 1971 Oct;51(1):344-8. doi: 10.1083/jcb.51.1.344.
4
Selective DNA synthesis by cells specifically localizing in response to xenogeneic erythrocytes.细胞通过对异种红细胞特异性定位进行选择性DNA合成。
J Exp Med. 1973 Sep 1;138(3):659-71. doi: 10.1084/jem.138.3.659.
5
Direct conversion of precursors of PFCs into active PFCs in vitro, without prior cell division.在体外将全氟化碳前体直接转化为活性全氟化碳,无需预先进行细胞分裂。
Immunology. 1973 Apr;24(4):707-10.
6
Cell cooperation in the immune response.免疫反应中的细胞协作。
Clin Exp Immunol. 1971 Jun;8(6):839-56.

本文引用的文献

1
Reactivation in vitro of immunocompetence in irradiated mouse spleen.照射鼠脾免疫活性的体外再激活。
J Exp Med. 1967 Aug 1;126(2):223-34. doi: 10.1084/jem.126.2.223.
2
Plaque Formation in Agar by Single Antibody-Producing Cells.琼脂中由单个抗体产生细胞形成的斑块。
Science. 1963 Apr 26;140(3565):405. doi: 10.1126/science.140.3565.405.
3
A THREE-CELL INTERACTION REQUIRED FOR THE INDUCTION OF THE PRIMARY IMMUNE RESPONSE in vitro.体外诱导初次免疫反应所需的三细胞相互作用。
Proc Natl Acad Sci U S A. 1968 Oct;61(2):542-7. doi: 10.1073/pnas.61.2.542.
4
Antibody formation initiated in vitro. II. Antibody synthesis in x-irradiated recipients of diffusion chambers containing nucleic acid derived from macrophages incubated with antigen.体外引发的抗体形成。II. 在接受含有与抗原孵育的巨噬细胞衍生核酸的扩散室的X射线照射受体中的抗体合成。
J Exp Med. 1963 Apr 1;117(4):595-602. doi: 10.1084/jem.117.4.595.
5
A requirement for two cell types for antibody formation in vitro.体外抗体形成需要两种细胞类型。
Science. 1967 Dec 22;158(3808):1573-5. doi: 10.1126/science.158.3808.1573.
6
Inhibition of plaque-forming cells by diethylaminoethyl dextran.二乙氨基乙基葡聚糖对空斑形成细胞的抑制作用。
J Bacteriol. 1967 Sep;94(3):791. doi: 10.1128/jb.94.3.791-.1967.
7
Immunization of dissociated spleen cell cultures from normal mice.对来自正常小鼠的脾细胞解离培养物进行免疫接种。
J Exp Med. 1967 Sep 1;126(3):423-42. doi: 10.1084/jem.126.3.423.
8
In vitro induction of the graft-versus-host reaction.移植物抗宿主反应的体外诱导
Exp Cell Res. 1966 Apr;42(1):31-41. doi: 10.1016/0014-4827(66)90316-8.
9
Primary antibody response in organ cultures.器官培养中的初次抗体反应。
J Exp Med. 1966 Nov 1;124(5):1001-16. doi: 10.1084/jem.124.5.1001.
10
Thymus-marrow cell combinations. Synergism in antibody production.胸腺-骨髓细胞组合。抗体产生中的协同作用。
Proc Soc Exp Biol Med. 1966 Aug-Sep;122(4):1167-71. doi: 10.3181/00379727-122-31353.