产生溶血素的细胞克隆的成熟。I. 体外对红细胞抗原的溶血素反应诱导期的动力学。
Maturation of hemolysin-producing cell clones. I. The kinetics of the induction period of an in vitro hemolysin response to erythrocyte antigen.
作者信息
Saunders G C
出版信息
J Exp Med. 1969 Sep 1;130(3):543-56. doi: 10.1084/jem.130.3.543.
Abstract
INVESTIGATIONS OF THE INDUCTION PERIOD OF AN IN VITRO HEMOLYSIN RESPONSE TO SHEEP ERYTHROCYTE ANTIGEN REVEALED THE FOLLOWING
- After antigen stimulation precursors of plaque-forming cells rapidly maturate to the point of hemolysin production. 2. Initial maturation probably occurs in the absence of cell division. 3. After initial maturation, a latent period of about 12 hr occurs before the first doubling of PFC. 4. At least the first three cell doublings are synchronous, with a generation time of 7-8 hr. 5. Synchronous cell division implies that all precursor cells are at the same point in the cell cyde when they are initially stimulated.
摘要
对体外针对绵羊红细胞抗原的溶血素反应诱导期的研究揭示了以下几点
- 抗原刺激后，形成噬斑细胞的前体细胞迅速成熟至产生溶血素的阶段。2. 初始成熟可能在无细胞分裂的情况下发生。3. 初始成熟后，在形成噬斑细胞首次倍增前会出现约12小时的潜伏期。4. 至少前三次细胞倍增是同步的，代时为7 - 8小时。5. 同步细胞分裂意味着所有前体细胞在最初受到刺激时处于细胞周期的同一阶段。
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Science. 1963 Apr 26;140(3565):405. doi: 10.1126/science.140.3565.405.
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A THREE-CELL INTERACTION REQUIRED FOR THE INDUCTION OF THE PRIMARY IMMUNE RESPONSE in vitro.体外诱导初次免疫反应所需的三细胞相互作用。
Proc Natl Acad Sci U S A. 1968 Oct;61(2):542-7. doi: 10.1073/pnas.61.2.542.
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Antibody formation initiated in vitro. II. Antibody synthesis in x-irradiated recipients of diffusion chambers containing nucleic acid derived from macrophages incubated with antigen.体外引发的抗体形成。II. 在接受含有与抗原孵育的巨噬细胞衍生核酸的扩散室的X射线照射受体中的抗体合成。
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6
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