发育中大鼠脑内髓磷脂及亚细胞组分的酶活性与组成
Enzyme activity and composition of myelin and subcellular fractions in the developing rat brain.
作者信息
Banik N L, Davison A N
出版信息
Biochem J. 1969 Dec;115(5):1051-62. doi: 10.1042/bj1151051.
Abstract
- Subcellular fractions and myelin were isolated from developing and adult rat brain. 2. Measurements of chemical composition and enzyme activities indicate the presence of a second myelin-like fraction mainly in the brain of developing rats. 3. This membrane fraction has a different lipid composition from myelin, but resembles myelin in its content of phosphohydrolase and aminopeptidase activity. 4. It is suggested that the second myelin-like fraction may be a submicrosomal contaminant or it may be derived from oligodendroglial plasma membrane during myelinogenesis.
摘要
- 从发育中和成年大鼠的大脑中分离出亚细胞组分和髓磷脂。2. 化学成分和酶活性的测量表明，主要在发育中大鼠的大脑中存在第二种髓磷脂样组分。3. 这种膜组分的脂质组成与髓磷脂不同，但在磷酸水解酶和氨肽酶活性含量方面与髓磷脂相似。4. 有人提出，第二种髓磷脂样组分可能是亚微粒体污染物，或者它可能在髓鞘形成过程中源自少突胶质细胞质膜。
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