松果体切除对大鼠免疫反应的影响。
Effect of pinealectomy on immune reactions in the rat.
作者信息
Janković B D, Isaković K, Petrović S
出版信息
Immunology. 1970 Jan;18(1):1-6.
Abstract
Non-inbred Wistar rats were pinealectomized at birth or in adult life, and tested for classical immune responses. Neonatal pinealectomy did not exert any notable effect on immune capacity of rats. On the other hand, rats pinealectomized at 6 weeks of age showed partial and transient impairment of immune potential. Arthus reactivity to bovine serum albumin was diminished and oedema of the skin less pronounced, and delayed reactions were reduced and of short duration. Slight delay in homograft rejection was noted. The incidence of allergic encephalomyelitis was diminished, and no clinical signs were observed. The cellular make-up of lymphoid tissues of pinealectomized adult rats was normal.
摘要
非近交系Wistar大鼠在出生时或成年后接受松果体切除，并进行经典免疫反应测试。新生期松果体切除对大鼠的免疫能力没有显著影响。另一方面，6周龄时接受松果体切除的大鼠免疫潜能出现部分和短暂的损害。对牛血清白蛋白的阿瑟反应性降低，皮肤水肿不那么明显，迟发型反应减少且持续时间短。同种异体移植排斥反应稍有延迟。过敏性脑脊髓炎的发病率降低，且未观察到临床症状。松果体切除成年大鼠的淋巴组织细胞组成正常。
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