Prakash O, Sharma R K, Nagchaudhuri J
Pharmacology. 1979;18(2):91-4. doi: 10.1159/000137235.
The pharmacokinetics of tritiated vinblastine in rats has indicated a considerable excretion of the alkaloid through bile into the intestinal lumen. The present study was undertaken to find out whether the presence of the alkaloid in the lumen of small intestine alters the normal transport of nutrients across the small intestine. This was done by measuring the in vitro D-glucose uptake by slices of small intestine of rats pretreated with vinblastine. Vinblastine pretreatment was done by filling the lumen of in vivo segments of small intestine of rats with different concentrations of the alkaloid for 30 and 60 min before uptake was measured. A significant dose-dependent reduction in D-glucose uptake was observed.
氚标记长春碱在大鼠体内的药代动力学研究表明，该生物碱可通过胆汁大量排泄至肠腔。本研究旨在探究小肠肠腔内该生物碱的存在是否会改变营养物质在小肠内的正常转运。通过测量用长春碱预处理的大鼠小肠切片对D-葡萄糖的体外摄取来进行研究。在测量摄取之前，通过向大鼠体内小肠段的肠腔内填充不同浓度的生物碱30分钟和60分钟来进行长春碱预处理。观察到D-葡萄糖摄取量呈显著的剂量依赖性降低。
