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巴仙吉犬因红细胞丙酮酸激酶缺乏导致的先天性溶血性贫血。

Congenital hemolytic anemia in the Basenji dog due to erythrocyte pyruvate kinase deficiency.

作者信息

Searcy G P, Miller D R, Tasker J B

出版信息

Can J Comp Med. 1971 Jan;35(1):67-70.

PMID:4251418
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1319543/
Abstract

Congenital hemolytic anemia in the Basenji dog resembles pyruvate kinase (PK) deficiency in man as it is characterized by an abbreviated erythrocyte life span, an intense reticulocytosis, type II autohemolysis and splenomegaly. Glucose utilization and lactate production were inadequate with respect to the immature cell population. Analysis of enzymes involved in erythrocyte glycolysis revealed a deficiency of pyruvate kinase.

摘要

巴仙吉犬的先天性溶血性贫血与人类的丙酮酸激酶（PK）缺乏症相似，其特征为红细胞寿命缩短、强烈的网织红细胞增多、II型自身溶血和脾肿大。相对于未成熟细胞群体，葡萄糖利用和乳酸生成不足。对参与红细胞糖酵解的酶进行分析发现丙酮酸激酶缺乏。

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Can J Comp Med. 1971 Jan;35(1):67-70.
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本文引用的文献

1
A specific erythrocyte glycolytic enzyme defect (pyruvate kinase) in three subjects with congenital non-spherocytic hemolytic anemia.三名先天性非球形红细胞溶血性贫血患者存在特定的红细胞糖酵解酶缺陷（丙酮酸激酶）。
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Pyruvate kinase (PK) deficiency hereditary nonspherocytic hemolytic anemia.丙酮酸激酶（PK）缺乏症导致遗传性非球形红细胞溶血性贫血。
Blood. 1962 Mar;19:267-95.
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Red-cell metabolism in non-spherocytic congenital haemolytic anaemia.非球形先天性溶血性贫血中的红细胞代谢
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Nonspherocytic congenital hemolytic anemia.非球形细胞性先天性溶血性贫血
Blood. 1960 Oct;16:1371-97.
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The photometric microdetermination of blood glucose with glucose oxidase.用葡萄糖氧化酶对血糖进行光度微量测定。
J Lab Clin Med. 1958 Mar;51(3):448-60.
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Studies on spontaneous in vitro autohemolysis in hemolytic disorders.溶血性疾病中自发性体外自身溶血的研究。
Blood. 1956 Nov;11(11):977-97.
7
Autohemolysis and other changes resulting from the incubation in vitro of red cells from patients with congenital hemolytic anemia.先天性溶血性贫血患者红细胞体外孵育导致的自身溶血及其他变化。
Blood. 1954 May;9(5):414-38.
8
Red cell metabolism in the premature infant. II. The pentose phosphate pathway.早产儿的红细胞代谢。II. 磷酸戊糖途径。
Pediatrics. 1967 May;39(5):689-95.
9
Familial nonspherocytic hemolytic anemia of Basenji dogs.巴仙吉犬的家族性非球形红细胞溶血性贫血
J Am Vet Med Assoc. 1969 Mar 1;154(5):503-7.
10
Familial anemia in the Basenji dog.巴仙吉犬的家族性贫血
J Am Vet Med Assoc. 1969 Jan 15;154(2):158-65.