Halberstadt E, Gerner R
Z Geburtshilfe Perinatol. 1979 Feb;183(1):1-11.
Several biophysical and biochemical changes are prerequisites for the adaptation of the newborn to extrauterine life. Enzyme induction is the mechanism on which this adaptation of metabolism is based. The theoretical fundamentals of enzyme induction are presented, and the perinatal origin of enzymes explained by means of the example of PEP carboxykinase. Among the mose frequent disturbances of the maturing of organs are hyperbilirubinaemias and the respiratory distress syndrome of newborn. The biochemical and physical concepts underlying these disease pattens are explained, and possibilities of enzyme induction and hence acceleration of maturity are shown. On the grounds of clinical experience, enzyme induction appears to be safely established as a membrane prophylaxis.
新生儿适应宫外生活需要一些生物物理和生化变化作为前提条件。酶诱导是这种代谢适应所基于的机制。本文介绍了酶诱导的理论基础，并以磷酸烯醇式丙酮酸羧激酶为例解释了酶的围产期起源。器官成熟过程中最常见的紊乱包括高胆红素血症和新生儿呼吸窘迫综合征。本文解释了这些疾病模式背后的生化和物理概念，并展示了酶诱导从而加速成熟的可能性。基于临床经验，酶诱导似乎已被安全确立为一种预防措施。
