Kuss E
J Clin Chem Clin Biochem. 1976 Nov;14(11):505-13.
The composition and structure of acellular alveolar material are described. Evidences as summarized that 1,2-dipalmityl-sn-glycero-phosphoryl-choline, depending of the presence of other components of the hypophasis, determines the surface tension of the air-alveolus interface. The foetal maturation of the lung is defined according to the Avery-Clements-Gluck theory, as a stabilisation of the alveolar lecthin production; and the dependence of the relevant enzyme activities on the stage of the pregnancy is discussed. Attention is drawn to the possibility of enzyme induction by medication; the biochemical and clinical aspects of the acceleration of lung maturation following glucocorticoid therapy are treated in detail. Finally, methods for the prepartal and postpartal characterisation of lung maturation,and especially the biochemical methods for the determination of lecithin in amniotic fluid, tracheal, and gastric secretion are discussed.
描述了无细胞肺泡物质的组成和结构。总结证据表明，1,2 - 二棕榈酰 - sn - 甘油 - 磷酸胆碱取决于垂体其他成分的存在，决定了气 - 肺泡界面的表面张力。根据艾弗里 - 克莱门茨 - 格鲁克理论，肺的胎儿成熟被定义为肺泡卵磷脂产生的稳定；并讨论了相关酶活性对妊娠阶段的依赖性。提请注意药物诱导酶的可能性；详细探讨了糖皮质激素治疗后肺成熟加速的生化和临床方面。最后，讨论了产前和产后肺成熟特征的方法，特别是测定羊水、气管和胃分泌物中卵磷脂的生化方法。
