Schmidt E W, Bender W, Breinl H, Meinen K, Ott J, Ott M
Z Geburtshilfe Perinatol. 1979 Feb;183(1):51-7.
The activity of the creatine kinase isoenzyme was measured in the serum of 133 healthy newborn. In contrast to the conditions in the adult, a normal range of 0-45 U/1 was found. No creatine kinase BMB activities were established. The increased creatine kinase-MB activities in newborn could be explained by means of an examination of the creatine kinase isoenzyme pattern in the skeleton muscle of foetuses and newborn. Depending upon the gestation age, creatine kinase-MB activity levels were found amounting to as much as a multiple of ten of the adult levels. Due to the deviation of the creatine kinase isoenzyme distribution in the organ tissue of newborn, identified in this study for the first time, creatine kinase-MB activity seems to be unsuitable as an indicator of myocardial damage during the neonatal period.
对133名健康新生儿的血清进行了肌酸激酶同工酶活性检测。与成年人的情况不同，发现正常范围为0 - 45 U/1。未检测到肌酸激酶BMB活性。新生儿肌酸激酶-MB活性升高可通过检测胎儿和新生儿骨骼肌中的肌酸激酶同工酶谱来解释。根据胎龄，发现肌酸激酶-MB活性水平高达成人水平的数十倍。由于本研究首次发现新生儿器官组织中肌酸激酶同工酶分布存在偏差，肌酸激酶-MB活性似乎不适用于作为新生儿期心肌损伤的指标。
