Harris D M, Gray P B
J Hyg (Lond). 1974 Oct;73(2):249-54. doi: 10.1017/s0022172400024098.
The incidence of infections caused by Pseudomonas aeruginosa did not increase significantly among general surgical and medical patients between 1967 and 1972, and the majority of such infections were trivial. Serious infections were virtually confined to the intensive care unit and the renal transplant unit, and were usually associated with major trauma, surgical mishap or immunosuppression. The majority of these patients had received prior antibiotic therapy. Persistent isolation of Ps. aeruginosa from surgical wounds was often associated with severe intra-abdominal sepsis, and antibacterial therapy was commonly ineffective in these cases. Apparently susceptible patients did not necessarily acquire infection, though the organism was present in their environment. It is suggested that this may reflect a variation of virulence among environmental strains of Ps. aeruginosa, and that further study of this aspect may contribute to improved control of infection.
1967年至1972年间，普通外科和内科患者中由铜绿假单胞菌引起的感染发生率并未显著增加，且大多数此类感染并不严重。严重感染几乎局限于重症监护病房和肾移植病房，通常与严重创伤、手术失误或免疫抑制有关。这些患者大多数此前接受过抗生素治疗。手术伤口持续分离出铜绿假单胞菌常与严重的腹腔内脓毒症相关，抗菌治疗在这些病例中通常无效。显然易感的患者不一定会感染，尽管该菌存在于其环境中。有人认为，这可能反映了环境中铜绿假单胞菌菌株毒力的差异，对这方面的进一步研究可能有助于改善感染控制。
